Tissue inhibitors of metalloproteases strike a nerve  

作　　者：veronica i.shubayev alex y.strongin 

机构地区：[1]department of anesthesiology,university of california,san diego [2]va san diego healthcare system,la jolla,ca,usa [3]sanford burnham prebys medical discovery institute,la jolla,ca,usa

出　　处：《Neural Regeneration Research》2018年第11期1890-1892,共3页中国神经再生研究（英文版）

基　　金：Department of Veteran’s Affairs Merit Review Award 5I01BX000638(to VIS);National Institutes of Health R01DE022757(to VIS and AYS)supported this study

摘　　要：Signals of touch,pressure,pain,temperature,position,and vibration are transmitted from the peripheral nervous system（PNS）to the dorsal horn of the segmental spinal cord via pseudounipolar dorsal root ganglia（DRG）neurons.Sensory information gathering relies on functional integrity of DRG neurons and can be interrupted by PNS injury due to trauma,disease or exposure to drugs, toxins or viral pathogens. Despite the high regenerative capacity of DRG neurons, sensory recovery after PNS injury is often incomplete and severe neuropathic pain may last for years. Although numerous mechanisms of PNS injury have been established, neuropathic pain is refractory to therapy, contributing to the physical and emotional suffering of patients and the enormous economic burden to society.Signals of touch,pressure,pain,temperature,position,and vibration are transmitted from the peripheral nervous system（PNS）to the dorsal horn of the segmental spinal cord via pseudounipolar dorsal root ganglia（DRG）neurons.Sensory information gathering relies on functional integrity of DRG neurons and can be interrupted by PNS injury due to trauma,disease or exposure to drugs, toxins or viral pathogens. Despite the high regenerative capacity of DRG neurons, sensory recovery after PNS injury is often incomplete and severe neuropathic pain may last for years. Although numerous mechanisms of PNS injury have been established, neuropathic pain is refractory to therapy, contributing to the physical and emotional suffering of patients and the enormous economic burden to society.

关 键 词：TIMPS PNS In Tissue inhibitors of metalloproteases strike a nerve 

分 类 号：R614[医药卫生—麻醉学]