浙江省成年人饮茶与脑卒中发生关联的前瞻性研究  

Association between tea drinking and stroke in adults in Zhejiang province： a prospective study

作　　者：王浩[1] 杜怀东[2] 胡如英[1] 钱一建 王春梅[3] 谢开婿[3] 陈玲琍 潘东霞[3] 卞铮 郭彧 俞敏[1] 李立明[5] 陈铮鸣[2] Wang Hao;Du Huaidong;Hu Ruying;Qian Yijian;Wang Chunmei;Xie Kaixu;Chen Lingli;Pan Dongxia;Bian Zheng;Guo Yu;Yu Min;Li Liming;Chen Zhengming(Department of Chronic and Non-communicable Disease Prevention and Control,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Clinical Trial Service and Epidemiological Studies Unit,Nuffield Department of Population Health,University of Oxford,Oxford OX3 7LF,United Kingdo;Department of Chronic and Non-communicable Disease Prevention and Control,Tongxiang County Center for Disease Control and Prevention,Tongxiang 314500,China;Department of China Kadoorie Biobank,Chinese Academy of Medical Sciences,Beifing 102308,Chin;School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]浙江省疾病预防控制中心慢性非传染性疾病预防控制所,杭州31005l [2]英国牛津大学纳菲尔德人群健康系临床与流行病学研究中心,OX37LF [3]桐乡市疾病预防控制中心慢病科,314500 [4]中国医学科学院慢性病前瞻性研究项目办公室,北京102308 [5]北京大学公共卫生学院,100191

出　　处：《中华流行病学杂志》2018年第9期1200-1205,共6页Chinese Journal of Epidemiology

基　　金：国家重点研发计划精准医学研究重点专项（2016YFC0900500,2016YFC0900501,2016YFC0900502,2016YFC0900504）;中国香港Kadoorie Charitable基金;英国Wellcome Trust（202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z）

摘　　要：目的探讨饮茶和成年人脑卒中发病的前瞻性关联。方法使用“中国慢性病前瞻性研究”（CKl3）浙江省桐乡市数据，剔除基线时自报患有恶性肿瘤、心脏病、脑卒中和糖尿病患者后，纳入分析30．79岁53916人。采用Cox比例风险模型计算脑卒中发病风险比（HR）。结果桐乡居民最主要的饮茶品种为红茶（79．78％），其次是绿茶（20．08％）。调查对象中，每周饮茶者的比例为31．27％，其中男性和女性分别为60．24％和10．30％；调查对象累计随访391512人年（平均随访7．26年）。随访期间，1487例男性和1769例女性被新诊断为脑卒中。在调整了人口社会学因素、生活方式、BMI、腰围和SBP等多种危险因素后，脑卒中发病风险随日均饮茶克数的增加而降低，趋势性检验差异有统计学意义（P=O．0006）。与非每周饮茶者相比，日均饮茶0．1～、3．0～和≥5．0g者脑卒中发病HR值（95％C1）分别为0．93（0．85～1．00）、0．88（0．77—0．99）和0．79（0．69～0．89）。与非每周饮茶者相比，日均饮茶≥5g者脑卒中发病HR值（95％CI）在吸烟和不吸烟人群中分别为0．71（O．59～0．86）和0．97（0．77～1．21），差异有统计学意义（P=0．0400），在不饮酒与饮酒的人群中分别为0．70（O．58-O．84）和0．96（0．76～1．22），差异有统计学意义（P=0．0400），在中心性肥胖与非中心性肥胖人群中分别为0．60（0．44～0．81）和0．86（0．73．1．01），差异有统计学意义（P=O．0400）。结论饮茶可以降低脑卒中发病风险。与非每周饮茶者相比，饮茶的保护作用在吸烟者、不饮酒者以及中心性肥胖者中更明显。Objective To prospectively explore the association between tea drinking and incidence of stroke of adults of Zhejiang province. Methods After excluding participants with heart disease, stroke, cancer and diabetes at baseline study, 53 916 participants aged 30-79 years in the China Kadoorie Biobank （CKB） study from Tongxiang were included for final analysis. Cox regression model was used to estimate the hazard ratio （FIR） for the association of tea drinking with incident stroke. Results The main type of drinking tea was black tea （79.78%）, followed by green tea （20.08%）. Of the 53 916 participants, the proportion of participants who drank tea at least once per week was 31.27%. The corresponding proportions for men and women were 60.24% and 10.30%, respectively. Among 391 512 person-years of the follow-up program （median 7.26 years）, a total of 1 487 men and 1 769 women were diagnosed with stroke. After adjusting for socio-demographic status, lifestyle, BMI, waist circumference, and systolic blood pressure, HR for incident stroke decreased with the increase of daily average tea consumption amount （P= 0.000 6）. Compared with participants who did not drink tea weekly, the HRs for incident stroke in those consuming tea 0.1-, 3.0- and ≥5.0 g/d were 0.93 （95% CI： 0.85-1.00）, 0.88 （95% CI： 0.77-0.99） and 0.79 （95% CI： 0.69-0.89）, respectively. The HRs for incident stroke in smokers and non-smokers who consumed tea ≥5.0 g/d were 0.71 （95%CI： 0.59-0.86） and 0.97 （95%CI：0.77-1.21）, respectively, compared with current smokers and non-smokers who did not drink tea weekly （P=0.040 0）. The corresponding HRs for alcohol drinkers and non-drinkers were 0.96 （95%C1： 0.76-1.22） and 0.70 （95%CI： 0.58-0.84）, respectively （P=0.040 0）. The corresponding HRs for central obese persons and non-central obese persons were 0.60 （95% CI： 0.44-0.81） and 0.86 （95% CI： 0.73-1.01）, respectively （P=0.040 0）. Conclusion Tea drinking had an effect on reducin

关 键 词：饮茶 脑卒中 前瞻性研究 

分 类 号：R743.3[医药卫生—神经病学与精神病学]