甘肃省强制戒毒者复方地芬诺酯滥用现状及相关因素分析  

Abuse of diphenoxylate and related factors of forced drug abstainer in Gansu province

作　　者：黄军军 荣右明 李荣成 李亚丽 杨艳旭 包凯芳 张俊华 刘宇琴 杜晓月 郑山[1] 白亚娜[1] Huang Juajun;Rong Youming;Li Rongcheng;Li Yali;Yang Yanxu;Bao Kaifang;Zhang Junhua;Liu Yuqin;Du Xiaoyue;Zheng Shan;Bai Yana(Institute of Epidemiology and Statistics,School of Public Health,Lanzhou University,Lanzhou 730000,Chin;Shandong Provincial Center for Adverse Drug Reaction Monitoring,Jinan 250014,China;Gansu Provincial Center for Drugs and Medical Devices Adverse Reaction Monitoring,Lanzhou 730000,China)

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计学研究所,730000 [2]山东省药品不良反应监测中心,济南250014 [3]甘肃省药品和医疗器械不良反应监测中心,兰州730000

出　　处：《中华流行病学杂志》2018年第9期1222-1227,共6页Chinese Journal of Epidemiology

基　　金：中央高校基本科研业务费专项资金重点项目（1zujbky-2017-k04）;兰州大学主干基础课程教学团队建设项目（820803-534000）

摘　　要：目的了解甘肃省强制戒毒者复方地芬诺酯滥用现状，探讨影响该人群滥用复方地芬诺酯的相关因素。方法采用自行设计的调查问卷，抽取甘肃省强制隔离戒毒所2108例戒毒者，开展横断面流行病学调查，了解戒毒者复方地芬诺酯的滥用现状；采用病例对照研究方法探讨影响该人群滥用复方地芬诺酯的相关因素。结果复方地芬诺酯在戒毒者中的滥用率为19．8％（406／2046），居该人群医疗用药物滥用首位。多因素logistic回归分析显示，滥用原因为缓解戒断症状（OR=2．08，95％CI：1．叭～4．32）、获得途径（其他途径：OR=1．00；正规诊所：OR=27．67，95％CI：2．64～289．82；朋友：OR=O．01，95％CI：0．01～O．03）、欣快感程度（高：OR=1．00；中：OR=3．36，95％CI：1．18～9．55；低：0R=26．16，95％CI：10．30-66．42）、滥用年限（〈5年：OR=1．00；10～15年：OR=2．48，95％C1：1．02～6．04）、滥用场所为自家或朋友家（OR=3．04，95％C1：1．08。8．68）、滥用场所为车内（OR=O．05，95％C1：0．00～0．68）和第一次脱毒（OR=O．61，95％CI：0．43～0．86）可能为复方地芬诺酯滥用的相关影响因素。结论甘肃省强制戒毒者复方地芬诺酯滥用率较高，滥用原因、获得途径、周围是否有同伴、欣快感程度、滥用年限、滥用场所和脱毒次数与该人群滥用复方地芬诺酯相关。Objective To investigate the prevalence of diphenoxylate abuse and related factors of forced drug abstainer in Gansu province. Methods By using a self-designed questionnaire, an epidemiologic investigation was carried out among 2 108 forced drug abstainer selected from the compulsory isolation detoxification center of Gansu province. A case-control study was conducted to analyze the factors related with diphenoxylate abuse. Results The diphenoxylate abuse rate among forced drug abstainer in Gansu was 19.8% （406/2 046）, ranking first in medical drug abuse. Multiple logistic regression analysis showed that factors as relieving withdrawal symptoms （OR=2.08, 95%C1： 1.01- 4.32）, ways to obtain diphenoxylate （other ways： OR= 1.00; regular clinic： 0R=27.67, 95%C1： 2.64-289.82; friend： OR=0.01, 95%CI： 0.01-0.03）, degree of euphoria （high： OR=1.00; medium：OR=3.36, 95%CI： 1.18-9.55; low： OR=26.16, 95%CI： 10.30-66.42）, years of drug abuse （〈5 years： OR=- 1.00; 10-15 years： OR==2.48, 95%CI： 1.02-6.04）, abuse at home or in friend＇s house （OR=3.04, 95%CI： 1.08-8.68）, abuse in car （OR=0.05, 95%CI： 0.00-0.68） and detoxification for the first time （OR=0.61, 95% CI： 0.43-0.86） were the possible influencing factors for diphenoxylate abuse. Conclusions The prevalence of diphenoxylate abuse in forced drug abstainer in Gansu was relatively high. Reasons of abusing, the way to obtain diphenoxylate, whether using drug together with friends, degree of euphoria, years of abuse, abuse place and times for detoxification were related factors influeneing the abuse of diDhenoxvlate.

关 键 词：复方地芬诺酯 药物滥用 相关因素 

分 类 号：R749.64[医药卫生—神经病学与精神病学]