寒潮诱发卒中：肾素-血管紧张素系统和基质金属蛋白酶-9的作用  

Cold wave-induced stroke： the roles of renin-angiotensin system and matrix metalloproteinas e-9

作　　者：李春光[1] 彭英[2] 谭盛[1] 黄如训[3] Li Chunguang;Peng Ying;Tan Sheng;Huang Ruxun(Department of Neurology,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China（Li CG,Tan S;Department of Neurology,Sun Yat-sen Memorial Hospital,Sun Yctt-sen University,Guangzhou 510120,China（Peng Y;Department of Neurology,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China（Huang RX)

机构地区：[1]南方医科大学珠江医院神经内科,广州510280 [2]中山大学孙逸仙纪念医院神经内科,广州510120 [3]中山大学附属第一医院神经内科,广州510080

出　　处：《国际脑血管病杂志》2018年第7期510-515,共6页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金（81500985）

摘　　要：流行病学调查和临床观察均表明低温可诱发高危个体的卒中发生，但其潜在机制仍不明确。研究显示，基质金属蛋白酶（matrix metalloproteinase，MMP）-9与动脉粥样硬化斑块以及脑动脉瘤的形成、发展和破裂有关，这是卒中发病的主要病理基础。寒冷可激活循环和组织的肾素-血管紧张素系统（renin-angiotensin system，RAS），而血管紧张素Ⅱ可诱导MMP-9表达和激活，后者进而可能导致动脉粥样硬化斑块或脑动脉瘤不稳定和破裂，从而触发卒中。Epidemiologieal studies and clinical observations have indicated that cold temperature can trigger the occurrence of stroke in individuals at high risk. However, the underlying mechanisms are still unknown. Matrix metalloproteinase-9 （MMP-9） has been found to be associated with the formation, progression and rupture of atherosclerotic plaques and cerebral aneurysms, which is the pathological basis of stroke. Cold temperature activates renin-angiotensin system （RAS） in circulation and tissue. Angiotensin Ⅱ has been implicated in the inducing MMP-9 expression and activation. An increase of MMP-9 may facilitate destabilization and rupture of atherosclerotic plaques or cerebral aneurysms, resulting in the occurrence of stroke.

关 键 词：卒中 冷温度 季节 肾素-血管紧张素系统 基质金属蛋白酶9 时间因素 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]