昆虫活性蛋白的功能和抗菌机制及开发利用研究进展  

Advances in Function,Antibacterial Mechanism and Utilization of Insect Bioactive Proteins

作　　者：杜晓童 廖森泰[2] 邹宇晓[2] 王维民[1] Du Xiaotong;Liao Sentai;Zou Yuxiao;Wang Weimin(College of Food Science and Technology,Guangdong Ocean University,Zhanjiang Guangdong 524088,China;Key Laboratory of Urban Agriculture in South China,Ministry of Agriculture,Sericulture and Agri-Food Research Institute,Guangdong Academy of Agricultural Sciences,Guangzhou 510610,China)

机构地区：[1]广东海洋大学食品科技学院,广东湛江524088 [2]广东省农业科学院蚕业与农产品加工研究所农业部华南都市农业重点实验室,广州510601

出　　处：《蚕业科学》2018年第4期638-644,共7页ACTA SERICOLOGICA SINICA

基　　金：广东省现代农业产业技术体系创新团队项目(No.2016LM1087,2016LM2151);广州市科技计划项目(No.2014J45-00036);广东省科技计划项目(No.2013B090600060);现代农业产业技术体系建设专项(No.CARS-18)

摘　　要：昆虫在漫长的进化过程中形成了由体液免疫和细胞免疫组成的独特免疫防御系统,以避免或减轻外界病原微生物侵入、物理损伤及逆境胁迫对机体造成的伤害。在此过程中,昆虫通过自身的免疫防御系统分泌出大量的具有特殊生理活性的蛋白质,包括抗菌肽、溶菌酶和凝集素等,这些特殊的蛋白质不仅在昆虫的生存活动和免疫反应中扮演着重要的角色,还在农业、医药和食品等领域显现出巨大的研究与潜在应用价值。本文对不同种类昆虫活性蛋白的化学结构、生理活性功能、抗菌机制和相关应用的研究进展,以及昆虫活性蛋白未来的研究方向进行综述。An unique immune defense system composed of humoral immunity and cellular immunity was developed in insects during long-term evolution process,which helps to protect insects from external pathogenic microorganism infection,physical damage and adversity stress,etc. During this process,insects secrete a large number of proteins with specific physiological activities including antimicrobial peptides,lysozymes and lectins through their own immune defense systems. These special proteins not only play important roles in insect survival and immune response,but also show great research and application potentials in agriculture,medicine and food sciences. In this paper,we reviewed the chemical structure,physiological activity,antibacterial mechanism research progresses of related applications and future research directions concerning these bioactive proteins.

关 键 词：昆虫活性蛋白 化学结构 生理活性 构效关系 抗菌剂 凝集素芯片 

分 类 号：Q966[生物学—昆虫学]