内生火热之毒致病特性探讨  

Discussion about the Pathogenic Characteristics of Endogenic Fire-toxin and Heat-toxin

作　　者：张昕洋 刘雪梅[2] 陈志刚[3] Zhang Xinyang;Liu Xuemei;Chen Zhigang(Beijing University of Chinese Medicine,Beijing 100029,China;Experiment Center,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China;First Department of Brain Diseases,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院实验中心,北京100078 [3]北京中医药大学东方医院病房十层脑病一科,北京100078

出　　处：《世界中医药》2018年第8期1845-1849,共5页World Chinese Medicine

基　　金：国家自然基金项目(81774250);国家国际科技合作专项(2015DFA31130);国家重点基础研究发展计划(973计划)项目(2012CB518406)

摘　　要：内生火热之毒(火毒)既是病理产物又是致病因素,其致病特性,引起当今中医学界广泛的关注和研究。火毒是在脏腑生理功能失调,气血津液运化失常的病理状态下,风、热、痰、瘀等诸邪内生,酿化蕴结,从热从火化生成毒,这是一个从量变到质变的过程。火毒一旦形成,除具有毒邪致病酷烈暴戾之性,突出特点是造成机体形质败坏,成为重大疾病临床突发、突变、进展,难治性疾病迁延恶化、难治难愈、难以逆转的主要原因和关键环节。Endogenic fire-toxin and heat-toxin are collectively referred to as the fire-toxin. The fire-toxin is both a pathological product and a pathogenic factor. The pathogenic characteristics of the fire-toxin have attracted extensive attention and research in traditional Chinese medicine. The imbalance in the physiological function of Zang-fu,the damage in transportation and transformation of Qi-blood-body fluid,all these phenomena lead to a specific pathological state of human body. In this pathological state,the pathogenic factors（ such as wind,heat,phlegm,blood stasis,etc.） are brewed and changed,turning into heat,then fire,finally the fire-toxin. This process is from quantitative change to qualitative change. Once the fire-toxin is formed,its cruel force destroys the substance of human body. Based on this prominent characteristic,the fire toxin is a key link in emergent occurrence,mutation,and evolvement of critical diseases,also a major cause of deterioration and refractoriness in refractory diseases.

关 键 词：内生火热之毒(火毒) 致病特性 

分 类 号：R226[医药卫生—中医基础理论]