骨桥蛋白的生物学功能及研究现状  

The function and research status of osteopontin

作　　者：赵嘉睿 邓卓越 穆莉莉[1] Zhao Jiarui;Deng Zhuoyue;Mu Lili(Department of Neurobiology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学神经生物学教研室,150081

出　　处：《国际免疫学杂志》2018年第4期448-451,共4页International Journal of Immunology

基　　金：国家自然科学基金面上项目（81471227）

摘　　要：骨桥蛋白（osteopomtin,OPN）是一种广泛分布的O-糖基化磷酸蛋白,又被称为分泌性磷蛋白1,骨涎蛋白1,Eta-1等,可以在如上皮,肾,骨和牙齿等的各种组织中表达,也可以在包括血液和母乳在内的所有体液中检测出.OPN在如细胞粘附和迁移、血管生成、免疫、神经发育和肿瘤转移等许多生理和病理过程中起作用.Osteopontin （OPN）is a widely distributed O-glycosylated phosphoric acid protein,also known as secretory phosphoprotein 1,bone sialoprotein 1,Eta-1,etc. ,Which is expressed in the epithelium,kid-ney,bone and teeth,etc. It is also found in all body fluids,including blood and breast milk. OPN plays a role in many physiological and pathological processes,such as cell adhesion and migration,angiogenesis,immunology, neurodevelopment and tumor metastasis.

关 键 词：骨桥蛋白 CD44 Β1整合素 

分 类 号：R363[医药卫生—病理学]