依达拉奉治疗急性百草枯中毒疗效的Meta分析  

A Meta-analysis on Curative Effect of Edarabone in Treatment of Acute Paraquat Poisoning

作　　者：檀立端[1] 武会志 陈治国[1] TAN Li-duan;WU Hui-zhi;CHEN Zhi-guo(Department of Emergency,Hebei Chengde Central Hosptial,Chengde Hebei,06700)

机构地区：[1]河北省承德市中心医院,河北承德067000

出　　处：《世界最新医学信息文摘》2018年第24期32-34,共3页World Latest Medicine Information Electronic Version

摘　　要：目的评价依达拉奉治疗急性百草枯中毒的治疗效果,为百草枯中毒的有效治疗提供循证医学依据。方法以"百草枯""依达拉奉为中文检索主题词,以"paraquat""edarabone"为英文检索主题词,检索检索Pub Med、EMbase、Cochrane、CBM、中国知网、万方和维普数据库,检索时限建库至2017年7月公开发表的论文,语种限定为中文和英文,收集依达拉奉联合常规治疗与常规治疗疗效对比的随机对照文献,筛选提取纳入研究的文献。采用5.3进行数据分析,比较依达拉奉联合常规治疗与常规治疗百草枯中毒的死亡率和肺纤维化率。结果共纳入7篇文献,依达拉奉联合常规治疗百草枯中毒的死亡率(95%置信区间0.28~0.64)和肺纤维化率(95%置信区间0.07~0.51),均低于常规对照组(P<0.0001;P=0.0008)。结论依达拉奉联合常规治疗百草枯中毒的死亡率和肺纤维化率,均低于常规治疗组。Objective To investigate the effectiveness of edarabone in the treatment of acute paraquat poisoning. We hope to it can provid evidence-based medicine for the therapy of paraquat poisoning. Methods The database such as Pub Med, EMbase, Cochrane, CBM, CNKI, Wan Fang and VIP Data were searched to collect randomized controlled trials published up to July, 2017. The subject words which included paraquat and edarabone were used for searching Chinese and English literature. Studies were screened, data were extracted. Rev Man5.3 were used for the analysis of the morbidity rate and pulmonary fibrosis rate after the edaravone combined with conventional treatment for acute paraquat poisoning. Results A total of 7 studies were included. The morbidity rate and pulmonary fibrosis rate of patients with edarabone combined with routine therapies for acute paraquat poisoning were significantly lower than those with routine therapies（OR=0.43, 95% CI=0.28 to 0.6, OR=0.20, 95% CI=0.07 to 0.51; P〈0.0001;P=0.0008）. Conclusions Edaravone combined with routine treatment for acute paraquat poisoning can reduce the mortality and pulmonary fibrosis rate.

关 键 词：依达拉奉 百草枯中毒 死亡率 肺纤维化率 META分析 

分 类 号：R781.66[医药卫生—口腔医学]