hTERC基因与宫颈癌患者病理特征的关系  

Relationship between hTERC gene and pathological characteristics of patients with cervical cancer

作　　者：荣晅[1] 侯春丽[1] 王爱玲[1] 马钰[1] RONG Xuan, HOU Chun-li, WANG Ai-ling, MA Yu(Shaanxi Provincal People＇s Hospital, Xi＇an 710068, China)

机构地区：[1]陕西省人民医院,陕西西安710068

出　　处：《临床医学研究与实践》2018年第28期10-11,共2页Clinical Research and Practice

基　　金：陕西省科学技术研究发展计划项目(No.2013K12-03-26)

摘　　要：目的研究人端粒酶m RNA基因(hTERC)与宫颈癌患者病理特征的关系。方法回顾性分析90例宫颈病变患者的临床资料,采用荧光原位杂交技术(FISH)检测hTERC基因表达水平,分析hTERC基因筛查宫颈癌的价值,记录CIN分级,比较不同病理类型宫颈癌患者中hTERC基因水平。结果宫颈癌患者hTERC阳性率显著高于非宫颈癌患者(P<0.05)。hTERC阳性率随CIN分级加重而升高(P<0.05)。不同FIGO分期、不同肿瘤分化程度及是否有淋巴结转移宫颈癌患者hTERC阳性率比较,差异均无统计学意义(P>0.05)。结论 hTERC基因有助于早期筛查宫颈癌,但在鉴别肿瘤分期、分化及病理分型方面具有一定局限性。Objective To study the relationship between hTERC gene and pathological characteristics of patients withcervical cancer. Methods The clinical data of 90 patients with cervical lesions were retrospectively analyzed. Theexpression level of hTERC gene was detected by fluorescence in situ hybridization （FISH）. The value of hTERC gene inscreening cervical cancer was analyzed. The CIN classification was recored, the hTERC gene levels of patients with cervicalcancer in different pathological types were compared. Results The positive rate of hTERC in patients with cervical cancerwas significantly higher than that in non -cervical cancer patients （P〈0.05）. The positive rate of hTERC in patientsincreased with CIN grades （P〈0.05）. There were no significant difference in the hTERC positive rates between differentFIGO stages, tumor differentiation and whether lymph node metastasis （P〉0.05）. Conclusion hTERC gene is helpful forearly screening of cervical cancer, but it has limitation in distinguishing tumor stage, differentiation and pathological typing.KEYWORDS： hTERC gene; cervical cancer; pathological features

关 键 词：HTERC基因 宫颈癌 病理特征 

分 类 号：R737.33[医药卫生—肿瘤]