血浆纤维蛋白原测定在脑血栓临床诊治中的应用价值  

Application value of determination of plasma fibrinogen in clinical diagnosis and treatment of cerebral thrombosis

作　　者：陈贤[1] CHEN Xian(Changshu No.2 People＇s Hospital, Changshu 215500, China)

机构地区：[1]常熟市第二人民医院,江苏常熟215500

出　　处：《临床医学研究与实践》2018年第28期40-41,共2页Clinical Research and Practice

摘　　要：目的探究脑血栓诊断中血浆纤维蛋白原测定的临床应用价值。方法将我院收治的脑血栓患者45例设为观察组,无心脑血管疾病的健康体检者45例设为对照组,采用免疫比浊法测定血浆纤维蛋白原水平,并分析纤维蛋白原水平与神经功能缺损程度的关系。结果治疗前,观察组纤维蛋白原水平高于对照组(P<0.05);治疗后,观察组纤维蛋白原水平逐渐降低(P<0.05),在治疗后1个月时恢复至正常,并与对照组无显著差异(P>0.05)。脑血栓神经功能轻度、中度及重度缺损患者的纤维蛋白原水平存在显著差异(P<0.05);且经Spearman相关性分析发现纤维蛋白原水平与神经功能缺损程度呈显著正相关(r=0.82,P<0.05)。结论血浆纤维蛋白原测定不仅可以作为脑血栓诊断的重要指标,在动态监测疾病治疗、判定神经受损程度方面也可提供临床指导意义。Objective To explore the clinical application value of determination of plasma fibrinogen in clinicaldiagnosis of cerebral thrombosis. Methods Forty-five patients with cerebral thrombosis admitted in our hospital were set asobservation group, and 45 healthy objects without cardiovascular and cerebrovascular diseases were set as control group.The levels of plasma fibrinogen were measured by immunoturbidimetry, and the relationship between fibrinogen levels anddegree of neurological deficit were analyzed. Results Before treatment, the level of fibrinogen in the observation group washigher than that in the control group （P〈0.05）. After treatment, the levels of fibrinogen in the observation group decreasedgradually （P〈0.05）, and returned to normal level at 1 month after treatment, which was no significant difference comparedwith the control group （P〉0.05）. The fibrinogen levels in mild, moderate and severe neurological deficit of cerebralthrombosis were significantly different （P〈0.05）, and Spearman correlation analysis showed that fibrinogen level waspositively correlated with degree of neurological deficit （r =0.82, P〈0.05）. Conclusion The determination of plasmafibrinogen can not only be used as an important indicator for the diagnosis of cerebral thrombosis, but also provide clinicalguidance in the dynamic monitoring of disease treatment and judging the degree of neurological deficit.

关 键 词：脑血栓 纤维蛋白原 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]