颅咽管瘤患者肿瘤部位与术后下丘脑-垂体功能的关系以及术后睡眠质量的影响因素  

Relation of lesion location with postoperative hypothalamus-pituitary function and influencing factors for postoperative sleep quality in craniopharyngioma patients

作　　者：黄建皓[1] HUANG Jian-hao(Department of Endocrinology,the People＇s Hospital of Guangxi Zhuang Auto,ruinous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院内分泌科,南宁市530021

出　　处：《广西医学》2018年第18期2159-2162,共4页Guangxi Medical Journal

摘　　要：目的探讨颅咽管瘤患者肿瘤部位与术后下丘脑-垂体功能的关系以及术后睡眠质量的影响因素。方法将59例颅咽管瘤成年患者根据肿瘤部位分为鞍区组24例、第三脑室组35例,比较两组的临床特点、垂体功能、术后肥胖(体质指数≥25 kg/m2)及睡眠障碍(匹兹堡睡眠指数>5分)的发生情况,分析颅咽管瘤患者术后睡眠障碍的影响因素。结果鞍区组的视力受损、肾上腺皮质功能减退及甲状腺功能减退患者比例均高于第三脑室组(均P<0.05);第三脑室组的睡眠障碍及肥胖患者比例高于鞍区组(均P<0.05)。术后肥胖是颅咽管瘤患者术后出现睡眠障碍的危险因素(P<0.05)。结论术后,鞍区颅咽管瘤患者更容易发生肾上腺轴、甲状腺轴功能减退,第三脑室颅咽管瘤患者更容易出现睡眠障碍及肥胖。颅咽管瘤术后肥胖患者出现睡眠质量下降的风险更高。Objective To explore the relation of lesion location with postoperative hypothalamus-pituitary function and influencing factors for postoperative sleep quality in craniopharyngioma patients. Methods Fifty-nine adult patients with craniopharyngioma were divided into sellar region group（ n = 24） and third ventricle group（ n = 35） according to the lesion location. The clinical features,pituitary function,and incidence of postoperative obesity（ body mass index≥25 kg/m2） and sleep disorder（ Pittsburgh Sleep Quality Index 5 points）were compared between the two groups. The influencing factors for postoperative sleep disorder in craniopharyngioma patients were analyzed. Results The proportions of the cases with visual impairment,adrenal deficiency and hypothyroidism in the sellar region group were higher than those in the third ventricle group（ all P〈0. 05）. The proportions of the cases with sleep disorder and obesity in the third ventricle group were higher than those in the sellar region（ all P〈0. 05）. Postoperative obesity was the risk factor for the incidence of postoperative sleep disorder in craniopharyngioma patients（ P〉0. 05）. Conclusion After operation,the adrenal and thyroid hypofunction are more common in the patients with sellar region craniopharyngioma,and sleep disorder and obesity are more common in the patients with the third ventricle craniopharyngioma. After craniopharyngioma surgery,the patients with postoperative obesity obtain high risk of sleep disorder.

关 键 词：颅咽管瘤 鞍区 第三脑室 睡眠质量 肥胖 垂体功能 影响因素 

分 类 号：R739.41[医药卫生—肿瘤]