MSCT联合血清VEGF、PCDGF检测用于肺癌诊断的敏感度与特异性探讨  

The sensitivity and specificity of MSCT combined with serum VEGF and PCDGF in the diagnosis of lung cancer

作　　者：黄权生[1] 李子平[2] 刘华[1] HUANG Quansheng1 , LI Ziping2, LIU Hua1(1. Department of Radiology, The Affiliated Hospital of Medical College of Jiaying University, Meizhou 514031, P. R. China; 2. Department of Radiology, The First Affiliated Hospital of Zhongshan University, Guangzhou 510055, P. R. China)

机构地区：[1]嘉应学院医学院附属医院放射科,广东梅州514031 [2]中山大学附属第一医院放射科,广东广州510055

出　　处：《医学影像学杂志》2018年第9期1465-1468,共4页Journal of Medical Imaging

基　　金：广东省广州市科技计划项目-科学研究专项一般项目(编号:2016E0442)

摘　　要：目的探讨多层螺旋CT(Multislice CT,MSCT)联合血管内皮生长因子(vascular endothelial growth factor,VEGF)、畸胎瘤源性细胞生长因子(PC cell-derived growth factor,PCDGF)检测用于肺癌诊断的敏感度与特异性。方法选取2009年2月～2014年2月来我院进行治疗肺癌患者120例,作为观察组;另选择同一时间来我院进行治疗的肺部良性病变患者60例,作为对照组。采用16排螺旋CT对其进行检测,并测定患者外周血中VEGF和PCDGF水平。分析MSCT单独诊断、血清标志物单独诊断和MSCT联合血清标志物诊断的敏感性和特异性。结果观察组患者MSCT图像中出现毛刺、分叶、微泡征和棘状突起的比例显著高于对照组患者(75 vs 8; 87 vs 14; 23 vs 2; 67 vs 4; P <0. 05)。观察组患者血清PCDGF和VEGF水平均显著高于对照组患者(18. 23±2. 32 vs 10. 65±1. 49; 1093. 4±193. 4 vs 523. 1±83. 7; P<0. 05),且观察组患者中血清PCDGF和VEGF的阳性检出率也显著高于对照组患者(103 vs 21; 92 vs 13; P <0. 05)。联合诊断可显著提高单独采用MSCT诊断或血清肿瘤标志物进行诊断的敏感性和特异性(91. 67%,93. 33%)。结论MSCT联合VEGF、PCDGF检测用于肺癌诊断的敏感度与特异性均优于MSCT和血清肿瘤标志物单独诊断的敏感度与特异性。Objective To explore the sensitivity and specificity of multislice CT combined with serum vascular endothelial growth factor and PC cell-derived growth factor in the diagnosis of lung cancer. Methods 120 patients with lung cancer coming to our hospital from February 2009 to February 2014 were selected as observation group. Another 60 patients with benign lung lesions coming for the treatment at the same period of time were selected as control group. The patients were examined by 64-slice spiral CT and the levels of VEGF and PCDGF in peripheral blood were measured. The sensitivity and specificity of MSCT alone diagnosis, diagnosis of serum markers and diagnosis of MSCT combined with serum markers were compared. Results The percentage of burrs, lobes, microbes and spinous processes in the MSCT images of the observation group was significantly higher than that of the control group （75 vs 8 ; 87 vs 14 ; 23 vs 2 ; 67 vs 4 ; P 〈 0.05）. The levels of serum PCDGF and VEGF in the observation group were significantly higher than those in the control group （ 18.23 ± 2.32 vs 10.65 ± 1.49 ; 1093.4 ± 193.4 vs 523.1 ± 83.7 ; P 〈 0.05 ） , and the positive rates of serum PCDGF and VEGF in the observation group were also significantly higher than those in the control group （ 103 vs 21 ; 92 vs 13 ; P 〈 0.05 ）. Joint diagnosis can significantly improve the sensitivity and specificity of diagnosis compared with using MSCT alone or serum tumor markers alone （91.67%, 93.33% ）. Conclusion The sensitivity and specificity of MSCT combined with VEGF and PCDGF in the diagnosis of lung cancer were superior to those of MSCT and serum tumor markers alone.

关 键 词：肺癌 体层摄影术 X线计算机 血管内皮生长因子 畸胎瘤源性生长因子 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]