经皮骨成形术联合动脉化疗栓塞治疗骨盆骨转移瘤  

Percutaneous osteoplasty combined with arterial chemoembolization for pelvic bone metastases

作　　者：巩庆雷 刘训伟[1] 周遵伟 王志国[1] 李尊勇[1] 谢志勇[1] 孙钢[1] GONG Qinglei1, LIU Xunwei1 , ZHOU Zunwei2 , FANG Zhiguo1 , LI Zunyong1 , XIE Zhiyong1 , SUN Gang1(1. Department of Medical hnage, Chinese PLA Jinan Military General Hospital, Jinan 250031, P. R. China ;2. Department of Oncology and Hematology, Qingdao Eighth People＇ s Hospital, Qingdao 266100, P. R. China)

机构地区：[1]中国人民解放军济南军区总医院医学影像科,山东济南250031 [2]山东省青岛市第八人民医院肿瘤血液科,山东青岛266100

出　　处：《医学影像学杂志》2018年第9期1540-1543,1547,共5页Journal of Medical Imaging

基　　金：国家自然科学基金资助项目(编号:81671799);国家高技术研究发展计划(863计划)资助课题(编号:2013AA032203)

摘　　要：目的比较经皮骨成形术和经皮骨成形术联合动脉化疗栓塞治疗骨盆骨转移瘤的临床疗效。方法 92例骨盆骨转移瘤患者,按治疗方案分为两组,对照组46例应用经皮骨成形术治疗,观察组46例应用经皮骨成形术联合动脉化疗栓塞术治疗。统计并比较分析两组患者疼痛目测类比评分、Karnofsky功能状态评分、MDA评价。结果 1)两组患者均顺利完成手术治疗; 2)两组患者治疗后的疼痛目测类比评分、Karnofsky功能状态评分均较治疗前改善(P <0. 05),两组组间比较差异无显著性意义(P> 0. 05); 3) MDA评价,实验组术后1个月和3个月骨转移瘤客观缓解率为78. 26%和69. 57%,高于对照组的54. 35%和47. 83%,2组比较差异有显著性意义(P <0. 05)。结论经皮骨成形术联合动脉化疗栓塞术对骨盆骨转移瘤的治疗有较好的效果,值得临床推广应用。Objective To compare the clinical curative effect of the pelvic metastases treated by the percutaneous osteoplasty and the percutaneous osteoplasty combined with transcatheter arterial chemoembolization. Methods 96 of patients with pelvic metastases were divided into two groups according to the treatment plan, 46 cases were chosen the percutaneous osteoplasty treatment, 46 cases were treated with percutaneous osteoplasty combined with transcatheter arterial chcmoembolization. We compared and analyzed the pain visual analogue scale, Kamofsky functional status score and MDA evaluation of the two groups. Results 1 ）The two groups of patients successfully completed the surgery; 2 ）The pain visual analogue scale, Kamofsky functional status score of the two group of patients after treatment were better than those before treatment （ P 〈 0.05）, there was no significant difference between the two groups （ P 〉 0.05 ） ; 3 ） For MDA evaluation, PR of the experimental group after 1 month and 3 months accounted for 78.26% and 69.57% , which was higher than the 54.35% and 47.83% of the standard group, these two groups had the significant differences （ P 〈 0.05 ）. Conclusion The results show that percutaneous osteoplasty combined with transcatheter arterial chemoembolization has a better effect for pelvic metastases treatment, which is worthy for clinical application.

关 键 词：骨盆骨 溶骨性 骨转移 经皮骨成形术 经导管动脉化疗栓塞术 

分 类 号：R738.1[医药卫生—肿瘤] R815[医药卫生—临床医学]