阿司匹林调控肿瘤细胞自噬机制的研究进展  

Research Progress in Mechanisms of Regulation of Tumor cell Autophagy by Aspirin

作　　者：詹沾 姜珊珊 刘洋[2] 刘傲然 罗志军[1] 应颖 ZHAN Zhana;JIANG Shan-shana;LIU Yangb;LIU Ao-ranc;LUO Zhi-juna;YING Yingd(a.Jiang~i Pro＇vincial Key Laboratory of Tumor Etiology and Molecular Patholog;b.the First Clinical Medical Colleg;c.the Fourth Clinical Medical Colleg;d.Department of Pathophysiology of School of Basic Medicine,Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学江西省肿瘤病原学与分子病理学重点实验室,南昌330006 [2]南昌大学第一临床学院,南昌330006 [3]南昌大学第四临床学院,南昌330006 [4]基础医学院病理生理学教研室,南昌330006

出　　处：《南昌大学学报（医学版）》2018年第4期81-84,共4页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81560299;81660163)

摘　　要：阿司匹林可通过多种信号通路调节细胞自噬而发挥其抗肿瘤作用。文章主要就阿司匹林通过AMPK依赖性和非依赖性途径诱导肿瘤细胞自噬的分子机制进行综述,为深入理解阿司匹林的防癌抗癌机制提供参考。Aspirin can inhibit the growth and differentiation of tumor cells by regulating auto phagy th pirin regulated multiple signaling pathways. This paper reviews the molecular mechanisms of as autophagy via AMPK dependent and independent pathways, which may provide areference for thoroughly understanding the mechanisms of aspirin action in the prevention and therapy of cancer.

关 键 词：阿司匹林 5′-单磷酸腺苷活化蛋白激酶 细胞自噬 肿瘤 分子机制 

分 类 号：R730.23[医药卫生—肿瘤]