紫杉醇脂质体药代动力学参数T_(c>0.05)在肺癌化疗中应用  

Correlation analysis between paclitaxel liposome pharmacokinetics parameter T_(c > 0. 05) and chemotherapeutic effect and safety in lung cancer

作　　者：李丽[1] 孙健[1] 钱婷[1] 朱旭 陈薛辉 黄新恩[1] LI Li;SUN Jian;QIAN Ting;ZHU Xu;CHENG Xue-hui;HUANG Xin-en(Nanjing Medical University Affiliated Cancer HospitcL Nanjing,Jiangsu 210029,China)

机构地区：[1]南京医科大学附属肿瘤医院江苏省肿瘤防治研究所江苏省肿瘤医院,江苏南京210029

出　　处：《临床肺科杂志》2018年第11期2013-2017,共5页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨在肺癌联合化疗过程中,紫杉醇脂质体药代动力学参数Tc> 0. 05与肺癌化疗近期肿瘤指标之间的相关性;并探究Tc> 0. 05值与肺癌化疗后副反应的相关性。方法选取14例病理学确诊的肺癌患者。所有患者接受紫杉醇脂质体联合卡铂的化疗方案,采用胶乳免疫比浊法检测患者血浆中紫杉醇脂质体的浓度,并应用紫杉醇脂质体群体药代动力学模型计算软件推算出Tc> 0. 05。通过病案记录采集病人信息,探讨Tc> 0. 05及紫杉醇脂质体血药浓度和化疗近期肿瘤指标的关系,以及与毒副反应的相关性。结果 Tc> 0. 05在化疗近期肿瘤指标变化上无明显统计学差异(P> 0. 05)。最常见的副反应白细胞下降Ⅰ-Ⅱ度和Ⅲ-Ⅳ度与Tc> 0. 05值有统计学差异(P <0. 05),Ⅲ-Ⅳ度白细胞下降患者所测Tc> 0. 05值高于Ⅰ-Ⅱ度白细胞下降者Tc> 0. 05值。结论紫杉醇脂质体药动参数Tc> 0. 05值与肺癌患者近期肿瘤指标相关性不显著。紫杉醇脂质体联合化疗最常见的副反应中,Tc> 0. 05值越高,患者越倾向于出现白细胞Ⅲ-Ⅳ度下降。Objective To investigate the correlation between liposomal paclitaxel pharmacokinetic parameters Tc 〉0.05 and short-term tumor markers response for patients with lung cancer who accepted L-PTX-based chemotherapy, and to explore the correlation between Tc 〉0.05 and side effect of chemotherapy. Methods Patients with histologieally or cytologically eolffirmed lung cancer were enrolled into this study. All patients enrolled eeeived L-PTX ＋ earboplatin （CBP）. It used latex imnmne turbidimetrie method to detect paelitaxel liposome in plasma concentrations, and paclitaxel liposome population pharmacokinetie model calculation software to calculate Tc〉0.05- Demographic characteristics, elinieopathologie characteristics and laboratory indexes were recorded according to medical records, and the relationship between the blood concentration of Tc 〉 0.05 and L-PTX and the recent tumor indexes of chemotherapy was analyzed, as well as the correlation with the toxic and side effects. Results There was no statistically significant difference in the recent tumor markers between chemotherapy and Tc〉0.05 （P 〉 0. 05）. The most common side effect were white blood cell decline, Ⅰ - Ⅱ degree and Ⅲ-Ⅳ degree, and the T 〉0.05 value was statistically different （P 〈0. 05）. The T 〉0.05 value of patients with Ⅲ-Ⅳ white blood cell decline was higher than that of Ⅰ - Ⅱ , and the T 〉0.05 value of WBC decreased. Conclusion Tc〉0.05 suggests to be no correlated with short-term tumor markers response for L-PTX based chemotherapy in treating patients with lung eameer, but it is found to be significantly increased in patients with grade Ⅲ-Ⅳ Leukocyte depletion.

关 键 词：紫杉醇脂质体 药代动力学参数 肺癌 肺癌肿瘤指标 毒副反应 

分 类 号：R734.2[医药卫生—肿瘤]