腹腔镜子宫肌瘤剔除术后氧化应激与疼痛的相关性研究  

Study on the correlation between oxidative stress and pain after laparoscopic myomectomy

作　　者：刘建国 蒋玉 范小艳 陈华盈 贺瑶 杨巍 Liu Jianguo, Jiang Yu, Fan Xiaoyan, Chen Huaying, He Yao, Yang Wei(Department of Gynaecology and Obstetrics, Changsha Hospital of Traditional Chinese Medicine （ Changsha Eighth Hospital）, Changsha 410100, China ; Department of Clinical Laboratory, Changsha Hospital of Traditional Chinese Medicine （Changsha Eighth Hospital ）, Changsha 410100, China)

机构地区：[1]长沙市中医医院(长沙市第八医院)妇产科,410100 [2]长沙市中医医院(长沙市第八医院)检验科,410100

出　　处：《中国医师杂志》2018年第9期1320-1323,共4页Journal of Chinese Physician

基　　金：湖南省省级科技计划项目(2013FL3129)~~

摘　　要：目的探讨腹腔镜子宫肌瘤剔除术后氧化应激与疼痛的相关性。方法选取2014年3月至2017年3月期间在长沙市中医医院接受治疗的子宫肌瘤患者84例,根据随机数字表法将患者分为对照组(n=42)和观察组(n=42)。对照组患者行常规的开腹子宫肌瘤剥除术,观察组患者行腹腔镜子宫肌瘤剔除术。比较两组患者术前、术后1、3 d的氧化应激指标[活性氧(ROS)、丙二醛(MDA)、晚期氧化蛋白产物(AOPP)]、疼痛指标[白细胞介素-6(IL-6)、心肌细胞P物质(SP)、前列腺素E2(PGE2)的水平以及视觉模拟量表(VAS)评分],采用Pearson相关分析方法分析氧化应激与疼痛的相关性。结果两组术后1、3d血浆中的ROS、MDA、AOPP水平均高于术前(均P<0.05);观察组术后1、3 d血浆中的ROS、MDA、AOPP水平均显著低于对照组(均P<0. 05);两组术后1、3 d血清中IL-6、SP、PGE_2的水平以及VAS评分均高于术前(均P <0.05);术后1、3 d观察组患者血清中IL～6、SP、PGE_2的水平以及VAS评分均低于对照组(均P <0. 05);Pearson相关分析结果显示,ROS、MDA、AOPP与PGE_2呈正相关(P <0. 05)。结论腹腔镜子宫肌瘤剔除术可有效降低子宫肌瘤患者术后出现的氧化应激反应,减轻术后疼痛,且术后氧化应激与疼痛指标PGE_2呈正相关。Objective To investigate the correlation between oxidative stress and pain after laparo scopic myomectomy. Methods 84 patients with uterine myoma who were treated in Changsha Hospital of traditional Chinese Medicine from March 2014 to March 2017 were enrolled in the study. The patients were divided into the control group （ n = 42 ） and the observation group （ n = 42） according to the random number table method. The patients in the control group were treated with conventional laparotomy hysteromyoma expetion, and the patients in the observation group were treated by laparoscopic myomectomy. The levels of oxidative stress indexes [ reactive oxygen species （ROS）, malondialdehyde （MDA）, advanced oxidation protein products （AOPP）] and pain indexes [intedeukin-6 （IL-6） , substance P （SP） , prostaglandin E2 （PGE2 ） and visual analogue scale （VAS） score] were compared between two groups before operation, 1 d after operation and 3 d after operation. Pearson correlation analysis was used to analyze the correlation between oxidative stress and pain. Results The levels of plasma ROS, MDA and AOPP in the two groups 1 d after operation and 3 d after operation were higher than those before operation （ all P 〈 0. 05 ）, the levels of plasma ROS, MDA and AOPP in observation group ld after operation and 3 d after operation were signifi- cantly lower than in the control group （ all P 〈 0. 05 ）. The levels of serum IL-6, SP, PGE2 and VAS score in the two groups 1 d after operation and 3 d after operation were all higher than those before operation （ all P 〈 0. 05 ） , the levels of serum IL-6, SP, PGE2 and VAS score in observation group after 1 d and 3 d after operation were all lower than those in control group （ all P 〈 0. 05 ）. The results of Pearson correlation analy-sis showed that ROS, MDA and AOPP was positively correlated with PGE2 （P 〈 0. 05 ）. Conclusions Laparoscopic myomectomy can effectively reduce the oxidative stress response to postoperative hysteromyoma

关 键 词：子宫肿瘤/外科学 平滑肌瘤/外科学 腹腔镜检查 氧化性应激 疼痛 手术后 

分 类 号：R737.33[医药卫生—肿瘤]