乳腺癌根治术后即刻乳房再造对患者生存质量和生存时间的影响  

The Influence of Immediate Breast Reconstruction on Postoperative Survival Quality and Survival Time of Patients after Radical Mastectomy

作　　者：白杰[1] 张晓宇 靳丽君 康晓宁[2] 刘伟[1] 王鹏[1] 王遵义[1] BAI Jie;ZHANG Xiao-yu;JIN Li-jun;KANG Xiao-ning;LIU We;WANG Peng;WANG Zun-yi(Department of Oncological Surgery;Department of Ultrasound,Cangzhou Central Hospital,Cangzhou,Hebei 061001,China)

机构地区：[1]沧州市中心医院肿瘤外三科,河北沧州061001 [2]沧州市中心医院超声二科,河北沧州061001

出　　处：《临床误诊误治》2018年第10期25-29,共5页Clinical Misdiagnosis & Mistherapy

基　　金：沧州市科学技术与发展指导计划项目(172302004)

摘　　要：目的探讨乳腺癌根治术后即刻乳房再造对患者生存质量和生存时间的影响。方法选取河北省沧州市中心医院肿瘤外三科2008年1月—2012年12月收治的152例乳腺癌患者,根据是否行乳房再造手术分为即刻乳房再造组(n=59)及非乳房再造组(n=93)。收集两组患者临床及随访资料,采用乳腺癌治疗功能评价量表(FACT-B)评价两组患者手术6个月后的生活质量,并比较两组5年内无复发生存率及总生存率。结果即刻乳房再造组手术6个月后FACT-B生理状况、功能状况、社会及家庭状况、附加关注状况和情感状况得分均明显高于非乳房再造组,差异均有统计学意义(P <0. 05或P <0. 01)。至随访结束,即刻乳房再造组5年无复发生存率(81. 36%)显著高于非乳房再造组(58. 06%),差异有统计学意义(χ~2=0. 825,P=0. 016);虽然即刻乳房再造组总生存率(84. 75%)稍高于非乳房再造组(81. 72%),但是差异无统计学意义(χ~2=3. 006,P=2. 175)。结论术后即刻行乳房再造能有效改善乳腺癌根治术后患者生活质量及提高5年内无复发生存率,但对5年内总生存率无明显影响。Objective To investigate the influence of immediate breast reconstruction on postoperative survival quality and survival time of patients after radical mastectomy. Methods A total of 92 patients with breast cancer treated in the Third Department of Oncology, Cangzhou Central Hospital, Hebei Province, fiom January 2008 to December 2012 were divided into the immediate breast reconstruction group （n = 59 ） and non-breast reconstruction group （ n = 93 ） according to breast reconstruction surgery that was performed of not. General information, clinical data and follow-up data of the patients in the two groups were collected. The quality of life of patients in the two groups after 6 months of operation was evaluated by Functional Assessment of Cancer Therapy-Breast Cancer （FACT-B） scale. In addition, the recurrence-fiee smwival （RFS） rate and overall smwival rate were compared between the two groups. Results At 6 months after surgery, physiological status, functional status, social and family status, the status of the additional attention and emotional state scores by FACT-B were significantly lower in non- breast construction group than in immediate breast reconstruction group, and there were significant differences （P 〈 0.05 or P 〈 0.01 ）. At the end of the follow-up period, the 5-year RFS rate was 81.36% in the immediate breast reconstruction group, which was remarkably higher than that （58.06%） of the non-breast reconstruction group, and the difference was statistically significant （χ^2 = 0. 825, P = 0. 016）. Although the total smwival rate of immediate breast reconstruction group was slightly higher than that of non-breast reconstruction group, and the difference was not statistically significant （ χ^2 = 3. 006, P = 2. 175 ）. Conclusion Immediate breast reconstruction after radical mastectomy can effectively improve life quality of patients and RFS rate within 5 years, but had no obvious influence on overall 5-year smwival rate.

关 键 词：乳腺肿瘤 即刻乳房再造 乳腺癌根治术 生存质量 生存时间 

分 类 号：R737.9[医药卫生—肿瘤]