多烯磷脂酰胆碱联合丁二磺酸腺苷蛋氨酸治疗急性病毒性瘀胆型肝炎患者的疗效  

Effects of polyene phosphatidylcholine combined with ademetionine 1,4-butanedisulfonate on patients with acute viral cholestatic hepatitis

作　　者：冯玉 吴洪川 郭义锦 韦玲[2] FENG Yu;WU Hong-chuan;GUO Yi-jin;WEI Ling(Department of Gastroenterology,the NO.4 Hospital of Haikou,Haikou 571100,China;Department of Gastroenterology,the Second Affiliated Hospital of Hainan Medical University,Haikou 570311,China)

机构地区：[1]海口市第四人民医院消化内科,海口571100 [2]海南医学院第二附属医院消化内科,海口570311

出　　处：《中国肝脏病杂志（电子版）》2018年第3期82-85,共4页Chinese Journal of Liver Diseases：Electronic Version

基　　金：2013年海南省自然科学基金(309118)

摘　　要：目的探讨烯磷脂酰胆碱联合丁二磺酸腺苷蛋氨酸治疗急性病毒性瘀胆型肝炎患者的疗效。方法选取2016年4月至2017年8月于海口市第四人民医院治疗的急性病毒性淤胆型肝炎患者144例为研究对象,采用随机数字表法将患者分为对照组和观察组,每组72例。对照组患者给予多烯磷脂酰胆碱治疗,15 ml静脉滴注,1次/天,疗程4周;观察组患者在对照组基础上加用丁二磺酸腺苷蛋氨酸,1.0 g静脉滴注,1次/天,疗程4周。比较两组患者治疗前后的生物化学指标,包括TBil、DBil、ALT、AST、IL-17和TNF-α等。结果治疗后观察组患者的TBil、DBil、ALT、AST、IL-17和TNF-α水平显著低于对照组,差异有统计学意义(P <0.05)。观察组有效率为90.3%(65/72),显著高于对照组的73.6%(53/72),差异有统计学意义(χ~2=2.524,P=0.036)。结论多烯磷脂酰胆碱联合丁二磺酸腺苷蛋氨酸可降低急性病毒性瘀胆型肝炎患者IL-17和TNF-α表达,加速黄疸消退,保护患者肝功能。Objective To investigate the effects of polyene phosphatidylcholine combined with ademetionine 1,4-butanedisulfonate on patients with acute viral cholestatic hepatitis. Methods Total of 144 patients with acute viral cholestatic hepatitis in the NO.4 Hospital of Haikou from April 2016 to August 2017 were enrolled. The patients were divided into control group and observation group according to random digital table method, 72 cases in each group. Patients in control group were intravenously dripped with 15 ml polyene phosphatidylcholine （one time per day） for 4 weeks, and patients in observation group were intravenously dripped with 1 g ademetionine 1,4-butanedisulfonate （one time per day） for 4 weeks on the basis of the control group. Blood biochemical indexes, including TBil, DBil, ALT, AST, IL-17 and TNF-α were compared between the two groups before and after treatment. Results After treatment, the level of TBil, DBil, ALT, AST, IL-17 and TNF-α of patients in observation group were significantly lower than those in control group, with statistically significant difference （P 〈 0.05）. The effective rate in observation group was 90.3% （65/72）, which was significantly higher than that of control group [73.6% （53/72）], with statistically significant difference （χ 2 = 2.524, P = 0.036）. Conclusions Polyene phosphatidylcholine combined with ademetionine 1,4-butanedisulfonate can reduce the expression of IL-17 and TNF-α, accelerate the decline of jaundice and protect the liver function of patients with acute viral choledocholic hepatitis.

关 键 词：瘀胆型肝炎 急性 病毒性 多烯磷脂酰胆碱 丁二磺酸腺苷蛋氨酸 免疫炎症反应 肝功能损伤 

分 类 号：R575.1[医药卫生—消化系统]