KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China  

作　　者：Song Hu Fahu Yuan Lingyan Feng Fang Zheng Feili Gong Hanju Huang Binlian Sun 

机构地区：[1]Medical College, Jianghan University [2]Department of Immunology, School of Basic Medicine,Tongji Medical College, Huazhong University of Science and Technology [3]Department of Pathogen Biology, Tongji Medical College,Huazhong University of Science and Technology

出　　处：《Virologica Sinica》2018年第4期369-372,共4页中国病毒学（英文版）

基　　金：supported by Grants from the National Major Science and Technology Project for Infectious Diseases of China(2012ZX10004503);Major State Basic Research Development Program of China(973 Program;No.2013CB530505)

摘　　要：Dear Editor,Natural killer(NK)cells are lymphocytes that play important roles in the host defense against hepatitis C virus(HCV)infection.Killer cell immunoglobulin-like receptors(KIRs)are a group of regulatory molecules expressed on NK cells and a subset of T cells(Parham 2005).Ligands for KIRs are human leukocyte antigen(HLA)class Ⅰ molecules,and HLA-C1 is a ligand for theDear Editor, Natural killer （NK） cells are lymphocytes that play important roles in the host defense against hepatitis C virus （HCV） infection. Killer cell immunoglobulin-like receptors （KIRs） are a group of regulatory molecules expressed on NK cells and a subset of T cells （Parham 2005）. Ligands for KIRs are human leukocyte antigen （HLA） class I molecules, and HLA-C1 is a ligand for the inhibitory receptors KIR2DL2, KIR2DL3 and the activating receptor KIR2DS2 （Robinson et al. 2003; Duet al. 2007）. In 2002.

关 键 词：丙肝病毒 风险因素 联合治疗 感染 遗传型 反应 中国 免疫球蛋白 

分 类 号：R512.63[医药卫生—内科学]