普鲁脂芬的合成工艺研究新进展  

New Research Progress in Synthesis of Procetofene

作　　者：郑绵冬 孙婷婷[1] 李敢[1,2] 王德堂 路文娟[1] 王苏文 ZHENG Miandong;SUN Tingting;LI Gan;WANG Detang;LU Wenjuan;WANG Suwen(Xuzhou College of Industrial Technology,Chemical Engineering Institure,Xuzhou 221140,China;Jiangsu Province Engineering Technolog Research and Development Center of New Chemical Material,Xuzhou 221140,China)

机构地区：[1]徐州工业职业技术学院化学工程技术学院,江苏徐州221140 [2]江苏省化工新材料工程技术研究开发中心,江苏徐州221140

出　　处：《化工技术与开发》2018年第10期31-32,49,共3页Technology & Development of Chemical Industry

基　　金：徐州工业职业技术学院科学技术项目(XGY2017A001)

摘　　要：普鲁脂芬是一种重要的降血脂原料药,其制剂具有良好的疗效。高效催化剂的选择是以非诺贝酸与异丙醇为原料合成普鲁脂芬的关键环节。本文参考了近几年有关普鲁脂芬合成的论文和专利,介绍了浓硫酸、硫酸氢钠、固体超强酸、离子交换树脂等催化剂催化合成普鲁脂芬的优化条件,分析了各种催化剂的优缺点,并指出了催化剂的研究发展方向。Procetofene was a kind of important Ingredient drug for lowering blood fat, its preparation had a good curative effect. Choosing a kind of high efficient catalyst for synthesis of procetofene with fenoberic acid and isopropyl alcohol as raw materials was an important step. The papers and patents on the synthesis of procetofene in recent years were referenced, optimization conditions about the synthesis of procetofene using the catalysts, such as concentrated sulfuric acid, sodium bisulfate, solid cuper acid, ion exchange resin were introduced, the advantages and disadvantages of these catalysts were analyzed, and the direction of research and development of catalysts were pointed out.

关 键 词：普鲁脂芬 合成 催化剂 进展 

分 类 号：R914.5[医药卫生—药物化学]