青光眼患者降眼压滴眼液治疗中发生眼表损伤的相关因素分析  

Related factors analysis of ocular surface injury in glaucoma patients treated with reduced intraocular pressure eye drops

作　　者：徐文云[1] 徐文霞 王小莉[3] 李琳 XU Wen-yun;XU Wen-xia;WANG Xiao-li;LI Lin(Ophthalmology Department,Xi＇an Gaoxin Hospital,Xi＇an 710075;Special Inspection Department,Xi＇an Aier EyeHospital,Xi＇an 710014;Ophthalmology Department,Xi＇an No.4 Hospital,Xi＇an 710004;Ophthalmology Department,Xi＇an Civil Aviation Hospital,Xi＇an 710082,China)

机构地区：[1]西安高新医院眼科,陕西西安710075 [2]西安爱尔古城眼科医院特检科,陕西西安710014 [3]西安市第四医院眼科,陕西西安710004 [4]民航西安医院眼科,陕西西安710082

出　　处：《临床医学研究与实践》2018年第29期84-85,共2页Clinical Research and Practice

基　　金：陕西省科学技术研究发展计划项目(No.2013K14-02-19)

摘　　要：目的分析青光眼患者降眼压滴眼液治疗中发生眼表损伤的相关因素。方法选择我院收治的110例(144眼)青光眼患者为研究对象,患者均行泪膜破裂时间(TFBUT)测定、荧光素角膜染色检查;按照是否发生眼表损伤分为损伤组(n=49)和未损伤组(n=61)。统计两组的性别、年龄、接受降眼压滴眼液治疗时间、青光眼病程及类型、滴眼次数等相关因素,并进行单因素和多因素分析。结果损伤组和未损伤组患者的年龄、接受降眼压滴眼液治疗时间、青光眼病程及点眼次数差异显著(P<0.05)。Logistic多因素分析结果显示,年龄、接受降眼压滴眼液治疗时间、青光眼病程、点眼次数等为青光眼患者降眼压滴眼液治疗中发生眼表损伤的危险因素(P<0.05)。结论年龄、接受降眼压滴眼液治疗时间、青光眼病程、点眼次数等为青光眼患者降眼压滴眼液治疗中发生眼表损伤的危险因素,因此临床应针对上述因素采取有效的防范措施。Objective To analyze the related factors of ocular surface injury in glaucoma patients treated withreduced intraocular pressure eye drops. Methods A total of 110 patients （144 eyes） with glaucoma were selected as thestudy objects, and the tear film breakup time （TFBUT） and fluorescein corneal staining were performed in all patients.According to whether there was ocular surface injury, all patients were divided into injured group （n=49） and uninjuredgroup （n=61）. The sex, age, received treatment time of reduced intraocular pressure eye drops, duration and type ofglaucoma and number of eye drops in the two groups were counted, and the univariate and multi factors analysis wereconducted. Results There were significant differences in age, received treatment time of reduced intraocular pressureeye drops, duration of glaucoma and number of eye drops between the injured group and the uninjured group（P〈0.05）.Logistic multivariate analysis results showed that age, received treatment time of reduced intraocular pressure eye drops,duration of glaucoma and number of eye drops were risk factors for ocular surface injury in glaucoma patients treatedwith reduced intraocular pressure eye drops （P 〈0.05）. Conclusion The age, received treatment time of reducedintraocular pressure eye drops, duration of glaucoma and number of eye drops were risk factors for ocular surfaceinjury. Therefore, effective preventive measures against these factors should be taken in clinic.

关 键 词：青光眼 降眼压滴眼液 眼表损伤 

分 类 号：R775.2[医药卫生—眼科]