内蒙古通辽市4549例女性感染人乳头瘤病毒亚型的分布特征分析  

Analysis of the Distribution Characteristics of the Subtypes of Human Papillomavirus Infection in 4549 Women in Tongliao City of Inner Mongolia

作　　者：姜宝玉 霍文艳[1] 刘雪杉 陈佳琦 翟率宇 杨立清[1] 白海花[1] JIANC;Bao-yu;HUO Wen-yan;LIU Xue-shan;CHEN Jia-qi;ZHAI Shuai-yu;YANG Li-qing;BAI Hai-hua(Affiliated Hospital,Inner Mongolia University for Nationalities,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学附属医院,内蒙古通辽028000

出　　处：《内蒙古民族大学学报（自然科学版）》2018年第5期447-451,共5页Journal of Inner Mongolia Minzu University：Natural Sciences

基　　金：内蒙古自治区科技厅科研基金资助课题(201502103)

摘　　要：目的:分析内蒙古通辽地区4549例女性宫颈脱落细胞人乳头状瘤病毒(HPV)基因分型的筛查结果,探讨HPV感染亚型在内蒙古通辽地区的分布特征.方法:采用PCR荧光探针法,对2016年11月～2017年9月在内蒙古民族大学附属医院自愿行宫颈病变筛查的4549例女性患者进行23种HPV基因分型检测,采用SPSS17.0统计学分析本地区女性宫颈23种HPV亚型的分布特征.结果:HPV感染的总体阳性率为28.25%(1285/4549),高危型阳性率为46.87%(2132/4549),低危型阳性率为12.13%(552/4549);感染的HPV亚型中,高危亚型阳性构成比排在前五位的是HPV16(18.83%,242/1285)、HPV58(17.04%,219/1285)、HPV52(13.39%,172/1285)、HPV53(8.56%,110/1285)、HPV59(6.85%,88/1285);低危型亚型阳性构成比排在前三位的是HPV6(9.49%,122/1285)、HPV42(8.09%,104/1285)、HPV81(7.00%,90/1285);单一感染和多重感染在HPV阳性的患者中所占的比例为65.53%和34.47%;感染的高峰年龄是≤20岁.结论:内蒙古通辽地区HPV感染率较高,主要为单一基因型感染,但多重感染的阳性占比较其他地区高,高危亚型以HPV16、58、52、53为主,低危亚型以HPV6、42、81为主.Objective： To analyze the screening results of human papillomavirus （HPV） genotyping in 4549 female cervical exfoliated cells in Tongliao, Inner Mongolia, and to explore the distribution characteristics of HPV subtypes in Tongliao region. Methods： Twenty-three HPV genotyping tests were performed on 4549 female patients, who were voluntarily screening for cervical lesions at the Affiliated Hospital of Inner Mongolia University for Nationalities from November 2016 to September 2017, using PCR fluorescent probe method. SPSS 17.0 statistics were used to an- alyze the distribution characteristics of 23 HPV subtypes of female cervix in this region. Results： The overall posi- tive rate of HPV infection was 28.25% （1285/4549）, the positive rate of high-risk type was 46.87% （2132/4549）, and the positive rate of low-risk type was 12.13% （55214549）. In the infected HPV subtypes, the top five proportion of high-risk subtypes were respectively HPV16 （18.83%, 24211285）, HPV58 （17.04%, 21911285）, HPV52 （13.39%, 17211285）, HPV53 （8.56%, 11011285） and HPV59 （6.85%, 8811285）; the top three proportion of low-risk subtypes were respectively HPV6 （9.49%, 122/1285）, HPV42 （8.09%, 104/1285） and HPV81 （7.00%, 90/1285）; the proportion of single infection and multiple infections in HPV-positive patients was respectively 65.53% and 34.47%, and the peak age of infection was no more than 20 years old. Conclusion： The infection rate of HPV in Tongliao area is relatively high, and mainly due to single genotype infection, but the proportion of multiple infection is higher than that of other areas. The high-risk subtypes are mainly HPV16, 58, 52 and 53, and the low-risk subtypes ares mainly HPV6, 42 and 81.

关 键 词：人乳头状瘤病毒 通辽地区 流行病学调查 

分 类 号：R737.33[医药卫生—肿瘤]