手足口病并脑炎患儿白细胞介素-1β、水通道蛋白4变化的意义  

Changes and clinical significance of interleukin-1β and aquaporin 4 in children with hand - foot - mouth disease combined with encephalitis

作　　者：王艳萍[1] 华颖[1] 王健彪[1] 井淼[1] Wang Yanping;Hua Ying;Wang Jianbiao;Jing Miao(Department of Neurology,Wuxi Children＇s Hospital,Wuxi 214023,Jiangsu Province,China)

机构地区：[1]无锡市儿童医院神经内科,214023

出　　处：《中华实用儿科临床杂志》2018年第18期1407-1410,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：无锡市医管中心联合攻关项目（YGZXL1323）

摘　　要：目的探讨手足口病并脑炎患儿白细胞介素-1β（IL-1β）、水通道蛋白4（AQP4）水平的变化及临床意义。方法选择2014年1月至2016年6月无锡市儿童医院诊治的手足口病患儿。其中手足口病普通病情患儿（普通组）30例，男13例，女17例；年龄（2.1±1.1）岁。手足口病并脑炎患儿（观察组）30例，男12例，女18例；年龄（2.4±1.2）岁。选择同期外科行腹股沟疝或睾丸鞘膜积液手术患儿26例为血清对照组，男25例，女1例；选择同期神经内科住院治疗的非中枢神经系统感染患儿26例为脑脊液对照组，男10例，女16例。采用酶联免疫吸附试验（ELISA）法检测观察组急性期、恢复期及手足口病普通组、血清对照组和脑脊液对照组患儿IL-1β及AQP4水平。结果观察组急性期及恢复期脑脊液IL-1β水平分别为（95.04±20.06） ng/L和（77.63±14.51） ng/L，脑脊液AQP4水平分别为（16.87±10.02） ng/L和（9.13±6.64） ng/L。观察组急性期、手足口病普通组血清IL-1β水平分别为（82.40±18.56） ng/L和（50.20±24.22） ng/L。观察组急性期脑脊液IL-1β、AQP4水平均较脑脊液对照组明显增高，差异均有统计学意义（均P〈0.05）；恢复期IL-1β、AQP4水平较急性期下降，差异均有统计学意义（均P〈0.05）。观察组急性期血清IL-1β水平较手足口病普通组明显增高，差异有统计学意义（P〈0.05）；手足口病普通组血清IL-1β较对照组增高，差异有统计学意义（P〈0.05）。结论AQP4及IL-1β可能通过促进脑水肿参与手足口病并脑炎的病理过程，可作为临床早期判断患儿病情严重程度的实验室指标之一。ObjectiveTo explore the changes and clinical significance of interleukin-1β（IL-1β） and aquaporin 4 （AQP4） in children with hand-foot-mouth disease （HFMD） combined with encephalitis.MethodsFrom January 2014 to June 2016, 30 cases of HFMD patients without encephalitis in Wuxi Children′s Hospital were selected as the general group, at an average age of （2.1±1.1） years, including 13 male and 17 female.Thirty cases of HFMD combined with encephalitis were selected as the observation group, at an average age of （2.4±1.2） years, including 12 male and 18 female.Twenty-six non-HFMD patients who underwent minor operations for inguinal hernia or hydrocele of testis were selected as the serum control group, including 25 male and 1 female.Twenty-six patients with non-infectious neurological disorders in the neurology department in the same period were selected as the cerebrospinal fluid control group, including 10 male and 16 female.The levels of AQP4 and IL-1β in children were detected by adopting enzyme-linked immuno sorbent assay（ELISA）.ResultsThe levels of IL-1β in cerebrospinal fluid in the acute phase and recovery phase of the observation group were （95.04±20.06） ng/L and （77.63±14.51） ng/L respectively, while the levels of AQP4 in cerebrospinal fluid were （16.87±10.02） ng/L and （9.13±6.64） ng/L respectively.The levels of IL-1β in serum in the acute phase of the observation group and the general group were （82.40±18.56） ng/L and （50.20±24.22） ng/L respectively.The levels of IL-1β, AQP4 in cerebrospinal fluid were significantly higher in the acute phase of the observation group compared with the controls, and the differences were statistically significant（all P〈0.05）. The levels of IL-1β and AQP4 in the recovery phase were lo-wer than those in the acute stage, and the differences were statistically significant（all P〈0.05）. The levels of IL-1β in serum was significantly higher in the acute phase of the observation group compared with the general

关 键 词：手足口病 脑炎 白细胞介素-1Β 水通道蛋白4 脑脊液 

分 类 号：R725.1[医药卫生—儿科]