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作 者:王志敢[1] 张娜[1] 赵艳[1] 刘爱凤[1] Wang Zhigan;Zhang Na;Zhao Ya_n;Liu Aifeng(Department of pathology,Changsha Central Hospital,Changsha,Hunan,410004,China)
出 处:《当代医学》2018年第29期31-35,共5页Contemporary Medicine
摘 要:目的探讨男性乳腺癌(male breast cancer,MBC)的临床病理学特点、治疗和预后。方法收集4例MBCs的临床病理学资料,显微镜下观察其HE及免疫组化切片,并复习相关文献。结果 4例MBC中左乳3例,右乳1例,平均发病年龄70.5岁,均表现为单侧乳晕区无痛性肿块,其中3例合并糖尿病。组织学类型IDC 2例,分子分型为Luminal A型,DCIS及黏液腺癌各1例。冰冻切片确诊为MBC后行患侧乳房单纯切除或改良根治术,3例未行放化疗,病例4化疗2个疗程。随访时间2~33个月不等,均无复发及转移,3例无瘤生存,1例IDC患者于术后33个月死于肺性脑病。结论 MBC极其罕见,其临床病理学特征与FBC存在差异,临床结局不定,预后与多因素相关。Objective To explore the clinicopathological features, therapy and prognosis of male breast cancers. Methods Clinicopathological data about 4 cases of MBC was collected, the HE and immunohistochemical sections were observed, and relevant literatures were combined. Results Among these MBCs, three cases originated from left breast and one from right, the average age was 70.5 years old. Most patients had pain- less mass in areola of the single breast, 3 cases with Diabetes mellitus. Histopathologically, Two cases were IDC-NOS, and molecular subtypes were Luminal A. DCIS and mucious adenocarcinoma was one case respectively. After MBCs were diagnosed by frozen section, the patients had a simple resection or modified radical mastectomy about the lesion breast. Three cases hadn't received radiotherapy or chemotherapy, only the fourth Case had received two courses of chemotherapy. The follow-up periods ranged from 2 to 33 months. All cases without recurrence or metastasis and three cases survived without disease. One patient with IDC was died of pulmonary encephalopathy 33 months after surgery. Conclusion MBCs is ex- tremely rare. The clinicopathological features are different from female breast cancers. Their outcome is uncertain and prognosis is associated with multifactors.
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