微小核糖核酸调控胆固醇稳态的研究进展  

Recent progress of microRNAs regulating cholesterol homeostasis

作　　者：张丽[1] 李强[1] Zhang Li;Li Qiang(Department of Endocrinology and Metabolism,The Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科,150081

出　　处：《国际内分泌代谢杂志》2018年第5期329-332,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（81170744,813709027）

摘　　要：胆固醇稳态受多种因素的密切调节,而胆固醇代谢紊乱与2型糖尿病、动脉粥样硬化、非酒精性脂肪性肝病等多种疾病的发生、发展密切相关.微小RNA（microRNA,miRNA）是脂代谢的转录后调控因子,miRNA-185-5p、miRNA-758-5p、miRNA-33a、miRNA-21、miRNA-122和miRNA-370与胆固醇的合成有关,miRNA-33、miRNA-144、miRNA-26、miRNA-758-3p、miRNA-106b、miRNA-10b、miR-NA-302、miRNA-145、miRNA-27a/b和miRNA-613与胆固醇的转运有关,多种microRNA共同参与调控胆固醇代谢中关键蛋白的表达,调控胆固醇的稳态平衡.Cholesterol homeostasis is tightly regulated by a series of factors,and perturbations incholesterol metabolism are associated with diseases such as type 2 diabetes,atherosclerosis and non-alcoholic fatty liver disease.microRNAs （miRNAs） are identified to be potent post-transcriptional regulators of lipid metabolism.miRNA-185-5p,miRNA-758-5p,miRNA-33a,miRNA-21,miRNA-122 and miRNA-370 have been shown to play important roles in regulating cholesterol synthesis,and miRNA-33,miRNA-144,miR-NA-26,miRNA-758-3p,miRNA-106b,miRNA-10b,miRNA-302,miRNA-145,miRNA-27a/b and miR-NA-613 have close relationships with cholesterol transport.microRNAs cooperate to regulate cholesterol homeostasis by regulating the expression of critical proteins in cholesterol metabolism.

关 键 词：胆固醇 MICRORNA 固醇调节元件结合蛋白 ATP结合盒转运体A1 

分 类 号：R363[医药卫生—病理学]