颅内原发性黑色素细胞瘤的临床特点  

Clinical characteristics of intracranial primary melanocytoma

作　　者：王新法[1] 何俊平[1] 高喆[1] 钱静[1] 祝永杰 邱德智 郑雷 张瑞[1] 王刚[1] WANG Xin-fa;HE Jun-ping;GAO Zhe(Department of Neurosurgery,Children＇s Hospital of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学附属儿童医院,210008

出　　处：《临床神经病学杂志》2018年第5期351-353,共3页Journal of Clinical Neurology

摘　　要：目的探讨颅内原发性黑色素细胞瘤的临床特点。方法对本院1例颅内原发性黑色素细胞瘤患者及文献报道的15例患者的临床资料进行回顾性分析,通过查阅复习相关文献,对这一罕见疾病进行探讨。结果 16例患者症状表现为头痛10例(62. 5%),头晕5例(31. 3%),呕吐4例(25. 0%),视力下降3例(18. 8%),面部麻木2例(12. 5%),嗅觉障碍2例(12. 5%),复视2例(12. 5%),行走不稳2例(12. 5%),听力下降1例(6. 3%),癫痫1例(6. 3%)。CT多数表现为均匀高密度占位性病变,MRI表现为短T1、短T2信号。治疗以手术切除为主,术后病理证实为黑色素细胞瘤。结论 CNS原发性黑色素细胞瘤发病率低,儿童脑内发病更为罕见,其生物学行为相对良性,治疗提倡早期手术。Objective To observe the clinical characteristics of intracranial primary melanocytoma. Methods The clinical data of 1 case of primary intracranial melanocytoma in our hospital and 15 cases reported in the literature were analyzed retrospectively. The rare disease was discussed by reviewing related literature. Results There were 16 patients in this group. Their symptoms were headache in 10 cases （62.5%） , dizziness in 5 cases （31.3%） , vomiting in 4 cases （25.0%） , decreased visual acuity in 3 cases （ 18.8% ）, facial numbness in 2 cases （ 12.5% ） , olfactory disorder in 2 cases （ 12.5% ） , diplopia in 2 cases （ 12.5% ） , walking instability in 2 cases （ 12.5% ）, hearing loss in 1 case （6.3%）, epilepsy in 1 case（6.3% ）. CT showed homogeneous and high density occupying lesion, and MRI showed short TI, short T2 signal. Surgical resection was the main treatment. Melanoma was confirmed by postoperative pathology. Conclusions The incidence of CNS primary melanocytoma is low. The incidence of children＇s brain is more rare. Its biological behavior is relatively benign. Treatment advocates early surgery.

关 键 词：黑色素细胞瘤 脑肿瘤 影像学 治疗 

分 类 号：R739.4[医药卫生—肿瘤]