Rsf-1在几种常见恶性肿瘤中的表达及意义  

Expression and significance of Rsf-1 in several common malignant tumors

作　　者：张金玉 乔树 陈保平[2] ZHANG Jinyu;QIAO Shu;CHEN Baoping(？ Medical Collage of Hebei University,Baoding 071000,China;？ Department of Breast Surgery,AffiliatedHospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学医学院,河北保定071000 [2]河北大学附属医院乳腺外科,河北保定071000

出　　处：《医学研究与教育》2018年第5期12-18,共7页Medical Research and Education

摘　　要：染色质重塑因子1 (Remodeling and spacing factor 1,Rsf-1)也叫做肝炎-BX相关蛋白(hepatities BX-antigen associated protein,HBXAP),在胃癌、肝癌、结肠癌等常见恶性肿瘤中均呈过表达的状态,并且该因子的过表达与恶性肿瘤细胞的增殖和恶性程度相关,高表达Rsf-1的患者往往具有更高的TNM分期、更差的预后。Chromatin remodeling factor 1（Rsf-1）, also known as hepatitis BX-antigen associated protein（HBXAP）, is overexpressed in common malignant tumors such as gastric, liver and colon cancer, and its overexpression is associated with the proliferation and malignancy grade of malignant cells. The patients with high Rsf-1 expression tend to have higher TNM stage and poorer prognosis.

关 键 词：染色质重塑因子1 恶性肿瘤 耐药性 细胞增殖 侵袭性 

分 类 号：R73[医药卫生—肿瘤]