β-环糊精及衍生物作为生物活性分子研究进展  

Research progress of β-cyclodextrins and its derivatives as active pharmaceutical ingredients

作　　者：张严 苏志桂[1] 张灿[1] ZHANG Yan;SU Zhigui;ZHANG Can(State Key Laboratory of Active Ingredients and Efficacy of Natural Drugs,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学天然药物活性组分与药效国家重点实验室,江苏南京210009

出　　处：《药学研究》2018年第10期589-592,611,共5页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81503006;81473153);江苏省自然科学基金(No.BK20150698)

摘　　要：β-环糊精为环状低聚糖,具有疏水内腔与亲水外层,其疏水内腔可与胞内胆固醇等脂质形成包合物,促进胞内蓄积脂质外排,调控胞内脂质稳态。近年来以β-环糊精及其衍生物为生物活性分子用于治疗尼曼-皮克C型疾病、阿尔兹海默病、缺血缺氧性脑病、动脉粥样硬化、癌症等疾病受到广泛关注。本文综述了β-环糊精及其衍生物作为生物活性分子在脂质失衡相关疾病治疗中的研究进展,为开发调控胞内脂质稳态类生物活性分子提供参考。β-Cyclodextrins are cyclic oligosaccharides that have a lipophilic cavity and a hydrophilic external surface.β-Cyclodextrins have the ability to encapulate hydrophobic molecule such as cholesterol,sphingolipids intracellularly,and promote the efflux of cholesterol and other lipids from the cell,finally regulate the homeostasis of cholesterol and other lipids.In recent years,researches on pharmacodynamics of β-cyclodextrins as well as their derivatives that have been used as active pharmaceutical ingredient for Niemann-Pick Type C disease,Alzheimer＇s disease,hypoxic-ischemic encephalopathy,atherosclerosis,cancer and other diseases have made some progress.This article summarized the research progress of β-cyclodextrins as well as their derivatives used as active pharmaceutical ingredient in various diseases,and aimed to provide reference for the advancement of β-cyclodextrin as well as their derivatives in the clinical research of various diseases through regulating lipid homeostasis.

关 键 词：Β-环糊精 包合物 脂质稳态 生物活性分子 药效学 

分 类 号：O636.12[理学—高分子化学]