复方鳖甲软肝片联合抗病毒药物治疗肝纤维化疗效观察  

Observation of curative effect of compound Biejia ruangan tablets with antiviral drug on liver fibrosis

作　　者：张健荣[1] 王忠成[1] 顾尔莉[1] 王世蓬[1] ZHANG Jian-rong;WANG Zhong-cheng;GU Er-li(The Third People＇s Hospital of Nantong City,Jiangsu Province,Nantong,226006,China)

机构地区：[1]江苏省南通市第三人民医院

出　　处：《山西中医》2018年第10期24-25,29,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：江苏省中医药局资助项目(编号:LZ13167);江苏省南通市科技局资助项目(编号:HS2013047)

摘　　要：目的:观察复方鳖甲软肝片联合抗病毒药物恩替卡韦治疗肝纤维化的疗效。方法:选取代偿期乙肝肝硬化74例,随机分成观察组42例与对照组32例,两组均予以恩替卡韦抗病毒及保护肝细胞治疗,观察组加用复方鳖甲软肝片,治疗随访24周,观察治疗前后无创肝纤维化诊断模型APRI、FIB-4指数及血清肝纤维化指标变化。结果:观察组治疗后无创肝纤维化模型评分APRI、FIB-4均较治疗前下降,差异有统计学意义(P﹤0.05),血清学指标HA、PCIII、CIV、LN、FN等治疗后也明显下降(P﹤0.05);对照组APRI、FIB-4虽有轻度下降,但无统计学差异(P>0.05),血清学指标仅HA、CIV较治疗前下降(P﹤0.05);组间比较,观察组APRI、FIB-4评分较对照组降低,差异有统计学意义(P﹤0.05),血清学PCIII、FN、LN与对照组比较均有统计学差异(P﹤0.05)。结论:复方鳖甲软肝片联合抗病毒治疗与单纯抗病毒治疗均有一定的抗肝纤维化作用,但联合治疗效果更好。Objective：To observe the effect of compound Biejia ruangan tablets combined with antiviral drug Entecavir on liver fibrosis. Methods：74 cases of selected patients with compensated hepatitis B liver cirrhosis were randomly divided into observation group of 42 cases and control group of 32 cases.Both groups were treated with antiviral drug Entecavir and protected the hepatocytes; while the observation group was treated plus with compound Biejia ruangan tablets,for 24 weeks.The changes of non-invasive hepatic fibrosis diagnosis model APRI,FIB-4 index and serum hepatic fibrosis indexes were observed. Results：After treatment,the scores of non-invasive hepatic fibrosis diagnosis model APRI and FIB-4 of observation group were lower than before treatment,and the difference was statistically significant（P〈0.05）. Serologic indexes HA,PCIII,CIV,LN,FN,etc. were also significantly lowered after treatment（P〈0.05）. However,APRI and FIB-4 of control group decreased slightly,but there was not statistical difference（P〉0.05）. Only HA and CIV in serologic indexes were lower than before treatment（P〉0.05）. Compared between two groups,the scores of APRI and FIB-4 after treatment in observation group were lower than in control group,and the difference was statistically significant（P〈0.05）.Compared with control group, serologic PCIII,FN,LN were with statistical differences（P〈0.05）. Conclusion：Compound Biejia ruangan tablets combined with antiviral treatment and simple antiviral treatment both have a certain degree of Anti-hepatic fibrosis,but the effect of combined treatment is better than that of monotreatment.

关 键 词：肝纤维化 复方鳖甲软肝片 恩替卡韦 中西医结合疗法 

分 类 号：R575.2[医药卫生—消化系统]