Anticancer activity and underlying mechanism of neogambogic acid  

作　　者：SUN Rui ZHANG Hong-Ming CHEN Bao-An 

机构地区：[1]Department of Hematology and Oncology,Zhongda Hospital,School of Medicine,Southeast University

出　　处：《Chinese Journal of Natural Medicines》2018年第9期641-643,共3页中国天然药物（英文版）

基　　金：supported by the Fundamental Research Funds for the Central Universities(No.KYLX15-0186);the Key Medical Projects of Jiangsu Province(No.BL2014078);the Key Discipline of Jiangsu Province(No.2016-2020)

摘　　要：Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that the main active monomer gambogic acid isolated from garcinia can inhibit the growth of various cancer cells. Neogambogic acid is an isolated compound with a similar chemical structure as gambogic acid. Preliminary studies show that the neogambogic acid can selectively inhibit the growth of various cancer cells, and has a broader antitumor activity and lower toxicity than gambogic acid. In this review, we summarize the advances made in the investigation of the anti-tumor effect of neogambogic acid in recent years.Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that the main active monomer gambogic acid isolated from garcinia can inhibit the growth of various cancer cells. Neogambogic acid is an isolated compound with a similar chemical structure as gambogic acid. Preliminary studies show that the neogambogic acid can selectively inhibit the growth of various cancer cells, and has a broader antitumor activity and lower toxicity than gambogic acid. In this review, we summarize the advances made in the investigation of the anti-tumor effect of neogambogic acid in recent years.

关 键 词：Chinese MEDICINE Neogambogic ACID ANTICANCER MECHANISM 

分 类 号：R965[医药卫生—药理学] Q5[医药卫生—药学]