酚妥拉明联合硝苯地平治疗子痫前期临床疗效观察  

Clinical Effect of Phentolamine Combined with Nifedipine on Preeclampsia Patients

作　　者：奚晟黎 张莉[1] Xi Shengli;Zhang Li(Department of Gynecology and Obstetrics,Huangpu District Central Hospital of Shanghai,Shanghai 200002,China)

机构地区：[1]上海市黄浦区中心医院妇产科,上海200002

出　　处：《成都医学院学报》2018年第5期616-620,共5页Journal of Chengdu Medical College

摘　　要：目的观察酚妥拉明联合硝苯地平治疗子痫前期的临床效果,并探讨其对机体抗氧化能力和Hcy水平的影响。方法选取2015年3月至2017年12月于上海市黄浦区中心医院治疗的子痫前期患者100例为研究对象,按照随机数字表法分为试验组和对照组,每组50例。对照组患者采用硝苯地平口服治疗,试验组患者在对照组治疗基础上,静脉滴注甲磺酸酚妥拉明,两组均治疗10d。比较两组患者治疗前后血压、血液粘稠度及24h尿蛋白定量水平;两组患者治疗前后抗氧化能力及Hcy水平;两组治疗疗效和不良妊娠结局。结果治疗后,试验组收缩压(SBP)、舒张压(DBP)、血液粘稠度和24h尿蛋白定量均明显低于对照组;试验组丙二醛(MDA)、脂质过氧化物(LPO)水平明显低于对照组(P<0.05);试验组总抗氧化能力(TAC)、超氧化物歧化酶(SOD)指标明显高于对照组(P<0.05);试验组同型半胱氨酸(Hcy)水平明显低于对照组(P<0.05);试验组治疗总有效率为96.00%(48/50),明显高于对照组的82.00%(41/50)(P<0.05);试验组不良妊娠结局发生率为6.00%(3/50),明显低于对照组的20.00%(10/50)(P<0.05)。结论酚妥拉明联合硝苯地平可以降低子痫前期患者的Hcy水平,改善患者机体抗氧化能力,提高临床治疗效果,降低不良妊娠发生率,值得推广应用。Objective To investigate the clinical effect of phentolamine combined with nifedipine on preeclampsia patients and its effect on the antioxidant capacity and homocysteine （Hcy） level. Methods A total of 100 preeclampsia patients treated in Huangpu District Central Hospital of Shanghai from March of 2015 to December of 2107 were selected as the research objects and divided into the experiment group and control group, and each group consisted of 50 cases. The control group was treated with oral phentolamine while the experiment group was given the intravenous drip of phentolamine mesylate as well as oral phentolamine. Both groups were treated for 10 days. The two groups were compared in blood pressure, blood viscosity, 24-hour urinary protein, antioxidant capacity and Hcy levels before and after treatment, respectively. The clinical effect and adverse pregnancy outcomes were also compared between two groups. Results After treatment, the levels of systolic blood pressure （SBP）, diastolic blood pressure （DBP）, blood viscosity and 24-h urinary protein were significantly lower in the experiment group than in the control group （ P 〈0.05）, while those of malondialdehyde （MDA） and lipid peroxide （LPO） were significantly lower in the experiment than in the control group （ P 〈0.05）. The Hcy level of the experiment group was significantly lower than that of the control group （ P 〈0.05）. The total effective rate of the experiment group was 96.00% （48/50） and it was significantly higher than that of the control group which was 82.00% （41/50） （ P 〈0.05）. The incidences of adverse pregnancy outcomes in the experiment group and control group were 6.00% （3/50） and 20.00% （10/50） respectively, and the difference was statistically significant （ P 〈0.05）. Conclusion Phentolamine combined with nifedipine can improve the clinical effect and reduce the incidence of adverse pregnancy outcomes by lowering the Hcy level and ameliorating the antioxidant capacity in preecl

关 键 词：子痫前期 硝苯地平 抗氧化能力 同型半胱氨酸 

分 类 号：R714.244[医药卫生—妇产科学]