miRNA-203表达水平对结直肠癌患者预后的临床价值  

The clinical value of miRNA-203 expression in predicting the prognosis of colorectal cancer patients

作　　者：方瑜洁[1] 张明丽[1] Fang Yujie;Zhang Mingli(Xi＇an First Hospital,Shaanxi Xi＇an 710002,China.)

机构地区：[1]西安市第一医院,陕西西安710002

出　　处：《现代肿瘤医学》2018年第21期3432-3436,共5页Journal of Modern Oncology

基　　金：陕西省自然科学基础研究(编号:2013JC2-14)

摘　　要：目的:探讨miRNA-203表达水平对结直肠癌患者预后的预测价值。方法:回顾性选择2010年1月至2013年12月来我院接受手术切除治疗的结直肠癌患者120例,所有患者均经病理确认。根据结直肠癌组织中miRNA-203表达水平将患者分为miRNA-203低表达组(n=42)和miRNA-203高表达组(n=78)。分析结直肠癌组织中miRNA-203表达水平与临床病理特征的关系,应用单因素、多因素非条件Cox回归分析影响结直肠癌患者预后的危险因素,并采用Kaplan-Meier法绘制累积生存曲线。结果:结直肠癌患者组织中miRNA-203表达量与年龄、性别、吸烟史、嗜酒史、组织类型、肿瘤位置、肿瘤直径无关(P> 0. 05),与分化程度、TNM分期、淋巴结转移、脉管浸润有关(P <0. 05)。单因素、多因素Cox回归分析结果显示,分化程度为高分化、TNM分期为IV期、组织中miRNA-203低表达是影响结直肠癌患者无进展生存率和总生存率的危险性因素(P <0. 05)。Kaplan-Meier法生存曲线结果显示,miRNA-203高表达组结直肠癌患者无进展生存率和总生存率显著高于低表达组(P <0. 05)。结论:miRNA-203表达水平可作为预测结直肠癌患者预后的指标。Objective To investigate the prognostic value of miRNA-203 expression in colorectal cancer patients. Methods： 120 patients with colorectal cancer in our hospital from January 2010 to December 2013 were selected as study subjects,all patients were confirmed by pathology.The patients were divided into miRNA-203 low expression group （ n =42） and miRNA-203 high expression group （ n =78） according to the expression level of miRNA-203 in tissues of colorectal cancer.The relationship between the expression level of miRNA-203 in tissues and clinicopathological characteristics in colorectal cancer patients were analyzed.Univariate and multivariate unconditional Cox regression analysis were used to analyze the risk factors of prognosis in colorectal cancer patients, and cumulative survival curves were drawn by Kaplan-Meier method. Results： The expression level of miRNA-203 in colorectal cancer tissues were independent of age,gender,smoking history,alcohol history,tissue type,tumor location and tumor diameter（ P 〉0.05）,which were related to differentiation,TNM stage,lymph node metastasis and vascular invasion（ P 〈0.05）.Univariate and multivariate unconditional Cox regression analysis showed that the degree of differentiation was high differentiation,TNM stage was IV stage,and low expression of miRNA-203 in tissues were the risk factor of progression free survival and overall survival rate in colorectal cancer patients（ P 〈0.05）.The survival curves of Kaplan-Meier showed that the progression free survival and overall survival rate in miRNA-203 high expression group were significantly higher than those in the low expression group（ P 〈0.05）. Conclusion： Expression of miRNA-203 in tissues can be used as a predictor of prognosis in patients with colorectal cancer.

关 键 词：结直肠癌 miRNA-203 无进展生存率 总生存率 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]