非典型抗精神病药物对不同性别青少年精神分裂症患者代谢的影响  

Metabolic Side Effects of Atypical Antipsychotic Agents on Adolescent Schizophrenia Patients of Different Sexes

作　　者：舒畅[1] 王晓萍[1] 刘靖[2] SHU Chang;WANG Xiao-ping;LIU Jing(Department of Psychiatry,WuhanUniversity,Renmin Hospital,Wuhan 430060,China;Mental health center for children,Peking Universitysixth hospital,Beijing 100083,China)

机构地区：[1]武汉大学人民医院精神卫生中心,武汉430060 [2]北京大学第六医院儿童心理卫生中心,北京100191

出　　处：《神经损伤与功能重建》2018年第10期508-510,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨不同性别青少年精神分裂症患者经抗精神病药物治疗4周前后体质量、空腹血糖(FBG)、血尿酸(UA)和血脂代谢的变化。方法:纳入住院治疗的青少年精神分裂症患者186例,男88例,女98例。给予相应的抗精神病药物治疗4周。比较治疗前、后患者体质量、血UA、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)水平及其变化。结果:与治疗前相比,女性青少年治疗4周后体质量、TG、LDL增高(P<0.05),FBG、TC、UA、HDL的血清水平,高TG血症的发生率和高UA血症发生率差异无统计学意义(P>0.05);男性青少年治疗4周后体质量,TG、LDL、UA的血清水平,高TG血症发生率增高(P<0.05),FBG、TC、HDL的血清水平,高UA血症的发生率差异无统计学意义(P>0.05);治疗4周后15.30%的女性青少年和15.91%的男性青少年体重增加了7%。结论:抗精神病药物治疗对青少年精神分裂症患者血脂和血UA代谢有影响,尤其是男性患者。Objective： To explore the changes in weight, fasting blood glucose （FBG）, serum uric acid （UA）,and lipid metabolism among adolescent schizophrenia patients of different sexes after 4-week treatment with atypical antipsychotic agents. Methods： One-hundred and eighty-six adolescent schizophrenia inpatients （88 males and 98 females） were involved in the study. Patients were treated with appropriate antipsychotic medication for 4 weeks. Weight, FBG, UA, triglyceride （TG）, total cholesterol （TC）, low-density lipoprotein （LDL）, and high-density lipoprotein （HDL） were measured before and after treatment, and the levels were compared. Results： In female patients, compared with baseline, a significant increase in weight, TG, and LDL was observed after treatment （P〈0.05）, and no significant difference was observed in FBG, TC, UA, HDL, and the incidence of hypertriglyceridemia and hyperuricemia （P〉0.05）. In male patients, compared with baseline, a significant increase in weight, TG, LDL, UA, and the incidence of hypertriglyceridemia was observed after treatment （P〈0.05）, and no significant difference was observed in FBG, TC, HDL, and the incidence of hyperuricemia （P〉0.05）. The weight of 15 female patients （15.30%） and the weight of 14 male patients （15.91%） increased 7% compared with those before treatment. Conclusion： Atypical antipsychotic agents have a certain affection on lipid and uric acid metabolism in adolescent schizophrenia, especially in male patients.

关 键 词：精神分裂症 血糖 血脂 尿酸 抗精神病药物 

分 类 号：R741[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]