原发性肝癌门静脉癌栓形成的影响因素分析  

Analysis of influencing factors of portal vein tumor thrombus in primary liver cancer

作　　者：徐静 谭林 高学武 王金玲 李风成 Xu Jing;Tan Lin;Gao Xuewu;Wang Jinling;Li Fengcheng(Department of Liver Disease 2,the Second Peoplet s Hospital of Fuyang,Fuyang 236000,China)

机构地区：[1]安徽省阜阳市第二人民医院肝脏病科二病区,236000

出　　处：《肿瘤研究与临床》2018年第9期610-612,616,共4页Cancer Research and Clinic

摘　　要：目的探讨原发性肝癌（PLC）患者门静脉癌栓形成的影响因素。方法 回顾性分析2012年6月至2016年12月安徽省阜阳市第二人民医院收治的483例PLC患者的临床资料，采用单因素分析及多因素logistic回归分析评估门静脉癌栓形成与常见临床因素的相关性。结果单因素分析结果显示，影响门静脉癌栓形成的因素有丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素、1-谷氨酰转肽酶、碱性磷酸酶、甲胎蛋白、肿瘤大小及数目、腹腔积液及肿瘤中心位置，差异均有统计学意义（P值分别为0．010、0．000、0．010、0．000、0．001、0．000、0．000、0．004、0．010）。logistic回归分析结果显示，甲胎蛋白及腹腔积液是门静脉癌栓形成的独立危险因素（P值分别为0．000、0．040）。结论门静脉癌栓多发生于甲胎蛋白水平偏高及合并腹腔积液的PLC患者。Objective To investigate the influencing factors of portal vein tumor thrombus in patients with primary liver cancer （PLC）. Methods A total of 483 patients with PLC in the Second People＂ s Hospital of Fuyang from January 2012 to December 2016 were included in this retrospective study. Univariate analysis and muhi-variate logistic regression analysis were employed to analyze the association between portal vein tumor thrombus and routine clinical parameters. Results The univariate analysis showed that alanine aminotransferase, aspartate aminotransferase, total bilirubin, ^-glntamyhranspeptidase, alkaline phosphatase, alpha-fetoprotein, the size and the number of tumors, ascites and center location of cancer performed a close relationship with the formation of portal vein tumor thrombus in patients with PLC, and the differences were statistically significant （P values were 0.010, 0.000, 0.010, 0.000, 0.001, 0.000, 0.000, 0.004 and 0.010）. Multivariate logistic regression analysis showed that potential significant predictors of portal vein tumor thrombus in patients with PLC were alpha-fetoprotein and ascites, and the differences were statistically significant （P values were 0.000 and 0.040）. Conclusion PLC patients with high level of alpha-fetoprotein and ascites are easier to induce the formation of portal vein tumor thrombus.

关 键 词：肝肿瘤 门静脉癌栓 甲胎蛋白类 腹水 

分 类 号：R735.7[医药卫生—肿瘤]