腹泻型肠易激综合征TH17细胞的免疫激活与食物过敏原相关关系  

Relationship between immune activation of TH17 cells and food allergen in diarrhea-predominant irritable bowel syndrome

作　　者：李金厚 袁海鹏[1] 石焕玲[1] Li Jinhou;Yuan Haipeng;Shi Huanling(Department of Gastroenterology,Central Hospital of Taian,Taian 271000,China)

机构地区：[1]泰安市中心医院消化内科,山东省271000

出　　处：《中华消化病与影像杂志（电子版）》2018年第5期203-206,共4页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的探讨腹泻型肠易激综合征(irritable bowel syndrome-diarrhea,IBS-D)血清白细胞介素17(interleukin 17,IL-17)及结肠黏膜病理中TH17细胞免疫激活及相关影响因素。方法根据罗马III诊断标准选取IBS-D病例组30例,取正常志愿者20人作为对照组。对研究对象检测血清IL-17含量及结肠黏膜病理标本中TH17细胞表达含量区别,及其与食物过敏原相关关系。结果 IBS-D组血清IL-17水平与正常对照组无明显差异。TH-17在结肠黏膜表达结果:IBS组在回盲部、横结肠、乙状结肠的TH17细胞计数及比例较正常对照组显著提高。IBS-D组较正常组食物过敏源种类(8. 0±4. 26比4. 9±3. 77)无明显差异,过敏原积分比较(20. 67±7. 96比3. 65±3. 65),差异有统计学意义;并在对青霉素(25/30比11/20)、牛奶(26/30比7/20)、羊肉(23/30比9/20)的过敏较正常组差异均有统计学意义。结论 IBS-D结肠黏膜存在TH17细胞免疫激活,与过敏因素有关,对临床个体化治疗有一定的参考意义。Objective To investigate the serum interleukin-17 （IL-17）and TH17 cells immune activation in eolonie nmeosa and the related influencing factors in diarrllea-predominant irritable bowel syndrome（IBS-D）. Methods A total of 30 IBS-D patients were selected as ease group according to the Rome ⅢIdiagnostie criteria,and 20 normal volunteers as a control group. The serum IL-17 and expression of TH17 cells in colonic nmeosa were detected, and their relationships with food allergen were analyzed. Results The difference d serum IL-17 level between the IBS-D group and the normal control group was not significant. The TH17 cell count and proportion of ileoeeeus, transverse colon, sigmoid colon in IBS-D group were significantly higher than those in the normal control group. There was no significant difference of food allergen category between the IBS-D group and the normal control group（ 8.0 ±4.26 vs. 4. 9 ±3.77）. There were significant differences in allergen scores（ 20. 67 ±7. 96 vs. 3.65 ± 3.65 ）, especially in penicillin（25/30 vs. 11/20） ,milk（26/30 vs. 7/20）and mutton（23/30 vs. 9/20）. Conclusion The colonic mueosa of IBS-D patient exists TH17 cells inmmne activation, which was associated with allergies, and it can guide individualized treatment in clinic.

关 键 词：腹泻型肠易激综合征 TH17细胞 白细胞介素17 过敏原 

分 类 号：R574.4[医药卫生—消化系统]