中医药调节胃癌炎症微环境的机制研究进展  

Progress of Chinese Medicine on Mechanism of Regulating Gastric Cancer Inflammatory-Microenvironment

作　　者：陈婉珍[1] 胡莹[1] 邵长乐 朱方石 CHEN Wanzhen;HU Ying;SHAO Changle;ZHU Fangshi(The Third Clinical Medical School of Nanjing University of Chinese Medicine,Nanjing 210028,Jiangsu,China;Jiangsu Provincial Academy of Traditional Chinese Medicine,Clinical Laboratory of Traditional Chinese Medicine and Western Medicine,Nanjing 210028,Jiangsu,China)

机构地区：[1]南京中医药大学第三临床医学院,江苏南京210028 [2]江苏省中医药研究院中西医结合临床研究室,江苏南京210028

出　　处：《中华中医药学刊》2018年第10期2484-2487,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81573966);国家中医临床研究基地业务建设科研专项项目(JDZX2012089)

摘　　要：胃癌是全球常见的恶性肿瘤之一,在我国胃癌的发病率高居恶性肿瘤第2位。近年来研究显示,肿瘤炎症微环境在胃癌的发生、侵袭及转移中均发挥重要作用。目前胃癌的治疗主要以手术联合化疗为主,但其5年生存率仍较低,且患者生活质量较差。中医药在提高患者免疫力及改善生活质量等方面具有一定优势。从中医药对肿瘤相关巨噬细胞、血管内皮生长因子及其受体、调节性T细胞及髓源性抑制细胞等胃癌炎症微环境的调节作用方面作一综述,为探讨中医药预防及辅助治疗胃癌的作用机制提供一定的思路。Gastric cancer is one of the most common malignant tumors in the world,and the morbidity of it accounted for the second place in China. Recent studies have shown that the tumor inflammatory-microenvironment plays an important role in the occurrence,invasion and metastasis of gastric cancer,and the main treatment of gastric cancer is surgery combined with chemotherapy at present. But the 5-year survival rate is still low,and the quality of life of the patients is poor. It is gradually recognized that traditional Chinese medicine（ TCM） has some advantages in improving the immunity and the quality of life. To provide some ideas on the mechanism of the preventive and auxiliary treatment of gastric cancer by traditional Chinese medicine,this paper will prove to review the effect of TCM on the regulation of the gastric cancer inflammatory-microenvironment on TAM,VEGF/VEGFR,Treg and MDSCs.

关 键 词：中医药 胃癌 肿瘤炎症微环境 研究进展 

分 类 号：R735.2[医药卫生—肿瘤]