金铃调胃汤治疗慢性萎缩性胃炎中EGF、VEGF、bFGF和NO等血管内皮因子的作用  

Effect of Jinling Tiewei Decoction on Vascular Endothelial Factor in EGF,VEGF,bFGF and NO in Chronic Atrophic Gastritis

作　　者：杨静[1] 栾静[2] 龙润[1] 杨金国[3] 冯庆涛[4] YANG Jing;LUAN Jing;LONG Run;YANG Jinguo;FENG Qingtao(Department of Digestive Endoscopy,Affiliated Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,China;Radiology Department,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,Hebei,China;Second Department of Spleen and Stomach Diseases,Affiliated Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,Chin;Department of Digestive Diseases,Affiliated Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,China)

机构地区：[1]河北省中医院消化内镜科,河北石家庄050011 [2]河北医科大学第二附属医院放射科,河北石家庄050000 [3]河北省中医院脾胃病二科,河北石家庄050011 [4]河北省中医院功能科,河北石家庄050011

出　　处：《中华中医药学刊》2018年第10期2546-2549,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2013032)

摘　　要：目的：探讨表皮细胞生长因子（Epidermal Growth Factor,EGF）、血管内皮生长因子（vascular endothelial growth factor,VEGF）、碱性成纤维细胞生长因子（fibroblast growth factor,b FGF）和一氧化氮（Nitric Oxide,NO）在金铃调胃汤治疗慢性萎缩性胃炎中的变化及意义。方法：120例慢性萎缩性胃炎患者随机分为两组,观察一组60例接受常规西药治疗,观察二组60例接受金铃调胃汤治疗。另选取健康体检者60例为对照组。治疗前后分别检测患者血清中EGF、VEGF、b FGF和NO的浓度变化。结果：观察一组和观察二组患者的疗效具有明显差异,观察一组有效率为93. 33%,观察一组有效率为76. 67%,差异具有统计学意义（P 〈0. 05）。与对照组相比,观察一组和观察二组患者血清内VEGF含量明显降低,患者血清内EGF含量明显上升,差异具有统计学意义（P 〈0. 05）。在不同疗法的药物治疗后,观察一组和观察二组患者血清VEGF、b FGF和NO含量明显上升,患者血清EGF含量明显下降,差异具有统计学意义（P 〈0. 05）。与观察一组患者相比,观察二组患者应用金铃调胃汤后血清内VEGF、b FGF和NO含量明显上升,患者血清内EGF含量明显下降差异具有统计学意义（P 〈0. 05）。结论：慢性萎缩性胃炎患者血清中EGF、VEGF、b FGF和NO的浓度在金铃调胃汤治疗前后具有明显变化; EGF、VEGF、b FGF和NO在慢性萎缩性胃炎的临床治疗过程中对病情的判断和治疗情况具有重要的提示作用。Objective： To investigate the expressions of epidermal growth factor（ EGF）,vascular endothelial growth factor（ VEGF）,basic fibroblast growth factor（ b FGF） and nitric oxide（ nitric oxide Oxide,NO） in the treatment of chronic atrophic gastritis by Jinling Tiewei Decoction. Method： A total of 120 patients with chronic atrophic gastritis were randomly divided into two groups. A group＇s 60 patients were treated with conventional western medicine. The other 60 cases were treated with Jinling Tongwei Decoction. Sixty healthy subjects were selected as the control group. The levels of EGF,VEGF,b FGF and NO in serum were measured before and after treatment. Result： There was significant difference between observation group 1 and 2. The effective rate was 93. 33% in the observation group 1 and 76. 67% in the observation group 2. The difference was statistically significant（ P〈0. 05）. Compared with the control group,the serum VEGF contents of observation group 1 and 2 were significantly reduced. The content of EGF in patients was significantly increased and the difference was statistically significant（ P〈0. 05）. After treatment with different therapies,the levels of serum VEGF,b FGF and NO were significantly increased in the observation group 1 and 2. The content of serum EGF in patients was significantly decreased and the difference was statistically significant（ P〈0. 05）. Compared with the observation group 1,the observation group 2＇s serum VEGF,b FGF and NO contents increased significantly and the difference of EGF content in the serum was statistically significant（ P〈0. 05）. Conclusion： The levels of EGF,VEGF,b FGF and NO in serum of patients with chronic atrophic gastritis have obvious changes before and after treatment with Jinling Tongwei Decoction. EGF,VEGF,b FGF and NO in the clinical treatment of chronic atrophic gastritis in the process of judging and treatment of the disease has an important role in suggesting.

关 键 词：慢性萎缩性胃炎 金铃调胃汤 EGF VEGF BFGF NO 

分 类 号：R573.32[医药卫生—消化系统]