108例青年肺癌患者临床病理特征分析  

Clinical pathological analysis of 108 young patients with lung cancer

作　　者：常秀军[1] 王子彤[1] 段勇[1] 李福根[1] CHANG Xiu-jun;WANG Zi-tong;DUAN Yong;LI Fu-gen(Department of Thoracic Surgery,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院胸外科,北京101149

出　　处：《中国肿瘤临床与康复》2018年第9期1029-1031,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨青年肺癌患者的临床病理特点。方法选取2012年1月至2017年5月间北京胸科医院收治的108例≤40岁青年肺癌患者为青年组,另选取50例60~75岁老年肺癌患者为老年组,比较两组患者的病理特征,采用Cox回归模型分析肺癌患者的预后影响因素。结果青年肺癌患者以腺癌、低分化程度、Ⅲ~Ⅳ期临床分期和无吸烟史为主,老年肺癌患者以鳞癌、中高分化程度、Ⅰ~Ⅱ期临床分期和有吸烟史为主,两组比较,差异均有统计学意义(均P<0.05)。青年组患者基因突变率高于老年组(P<0.05),而老年组患者手术治疗率高于青年组(P<0.05);两组患者确诊时机均以初次就诊为主,且老年患者初次就诊确诊率较高;两组患者就诊原因均以有症状为主,且青年组患者有症状就诊率较高;差异均有统计学意义(均P<0.05)。青年组患者中位生存时间为20个月,5年生存率为14.8%,老年组患者中位生存时间为21个月,5年生存率为14.0%,两组比较,差异无统计学意义(P>0.05)。Cox回归分析结果显示,患者是否吸烟、病理分化、TNM分期及EGFR基因突变是影响预后的独立因素,差异均有统计学意义(均P<0.05)。结论青年肺癌患者以腺癌、低分化程度、Ⅲ~Ⅳ期临床分期和无吸烟史为主,患者是否吸烟、病理分化、TNM分期及EGFR基因突变是影响预后的独立因素。Objective To investigate the clinical characteristics in young patients with lung canc- er. Methods From January 2012 to May 2017, 108 patients ≤40 years with lung cancer were selected at Beijing Chest Hospital and 50 patients at 60 ~ 75 years with lung cancer were selected at the same time. The pathological characteristics were analyzed and compared between the elderly patients and the young patients. Cox regression model was used to analyze factors influencing the prognosis. Results The young patients with lung cancer were characterized by adenoearcinoma, low degree of differentiation, Ⅲ~ Ⅳ TNM staging and non-smoking history and the elder patients were characterized by squamous cell carcinoma, high degree of differentiation, I ~ Ⅱ TNM staging and smoking history （ all P 〈 O. 05 ）. Gene mutation did not oc- curred in most patients in both groups and the percentage of non-gene mutation was higher in elder patients than in young patients. Surgery was the primary treatment strategy for both groups and the incidence of sur- gery was higher in in elder patients than in young patients. The diagnostic time was the initial diagnosis for most patients in both groups and the initial diagnosis rate was was higher in in elder patients than in young patients. Both groups visited the hospitals with some symptom and the visit rate was higher in young patients with symptom than in elder patients （ all P 〈 0.05 ）. The median survival was 20 months for the young group and 21 months for the eld group and the 5-year survival was 14. 8% for the young group and 14.0% for the eld group （P〉0.05）. Cox regression analysis revealed that smoking history, pathological differentiation, TNM staging and EGFR mutation were independent factors influencing the prognosis （ all P 〈 0. 05 ）. Conclusion The young patients with lung cancer were characterized by adenocarcinoma, low degree of dif- ferentiation,Ⅲ~ Ⅳ TNM staging and non-smoking history. Smoking history, pathological differentiation, TNM staging and EGF

关 键 词：肺肿瘤 青年人 临床特点 

分 类 号：R734.2[医药卫生—肿瘤]