抗幽门螺杆菌治疗对血液肿瘤化疗患者胃肠道反应的影响  

Effect of Anti-Helicobacter Pylori Therapy on Gastrointestinal Tract Response in Hematologic Cancer Patients

作　　者：喻琴 黄婷 胡正清 彭莉 马广渊 YU Qin;HUANG Ting;HU Zhengqing;PENG Li;MA Guangyuan(Ganxi Cancer Hospital,Pingxiang 337000,China)

机构地区：[1]赣西肿瘤医院,江西萍乡337000 [2]湘雅萍矿合作医院,江西萍乡337000

出　　处：《现代医院》2018年第9期1337-1339,1342,共4页Modern Hospitals

摘　　要：目的探讨抗幽门螺杆菌(HP)治疗对血液肿瘤化疗患者胃肠道反应的临床效果。方法选取2017年3月—2018年3月的56例血液肿瘤患者(主要为白血病、淋巴瘤、多发性骨髓瘤患者),其中有30例幽门螺杆菌感染患者,选取这30例患者作为本次观察的目标对象,并将其随机分为对照组(实施止吐药物进行治疗,n=15),观察组(在对照组的基础上实施抗幽门螺杆菌进行治疗,其主要药物有奥美拉唑20 mg bid+克拉霉素500 mg bid+阿莫西林1 000 mg bid+磷酸铝凝胶20 mg bid,n=15),应用WHO胃肠道反应分度的标准对其进行全面评价,并应用14C-尿素呼气试验对幽门螺杆菌的根除率进行有效评估。比较两组患者消化道肿瘤患者FLIE评分、HP感染加重呕吐反应,以及治疗呕吐有效率的情况。结果接受化疗并伴有幽门螺杆菌感染患者与未感染者进行比较,其呕吐程度较严重,其中Ⅲ～Ⅳ度呕吐(χ~2=35. 337,P <0. 05),Ⅰ～Ⅱ度呕吐(χ~2=7. 602,P <0. 05),数据对比存在明显的差异(P <0. 05);观察组在恶心、呕吐部分中的得分与对照组得分进行比较,观察组明显优于对照组,两组数据对比可知,存在明显的差异(P <0. 05);观察组的治疗呕吐总有效率为93. 3%,明显高于对照组,两组数据对比可知,存在明显的差异(P <0. 05)。结论在对照组的基础上应用抗幽门螺杆菌进行治疗对于血液肿瘤化疗患者胃肠道反应具有积极作用,可以有效改善血液肿瘤患者化疗所致的呕吐情况,在临床上值得推广应用。Objective To investigate the clinical effect of anti helicobacter pylori （HP） therapy on gastrointesti- nal reactions in patients with hematological tumor chemotherapy. Methods Fifty six patients with hematological tumors （mainly leukemia, lymphoma, and multiple myeloma） from March 2017 to March 2018 were selected. Among them, 30 pa- tients with Helicobacter pylori infection were selected. These 30 patients were selected for this observation. The subjects were randomly divided into control group （ treated with antiemetic drugs, n = 15 ） and observation group （ on the basis of control group, anti - Helicobacter pylori treatment was perforated, the main drugs were （ Omera Azole 20 mg bid ＋ clarithromycin 500 mg bid ＋ amoxicillin 1 000 mg bid ＋ aluminum phosphate gel 20 mg bid, n = 15 ）. The WHO GI grading scale was used to evaluate it and 14C - urea was used. The gas test can effectively evaluate the eradication rate of Helicobacter pylori and compare the efficacy of treatment and the aggravated vomiting response of HP infection. Results Patients who received chemotherapy and were infected with Helicobacter pylori were more severely vomiting, with III -IV vomiting （ χ2 = 35. 337, P 〈 0.05 ） and I - II vomiting （ χ2 = 7. 602, P 〈 0.05 ）, there was a significant difference in data comparison （ P 〈 0.05 ）. The scores of the observation group in the nausea and vomiting were compared with those in the control group. The observation group was significantly better than the control group. The difference was statistically significant （P 〈 0.05 ）. The total effec- tive rate of treatment for vomiting in the observation group was 93.3%, which was significantly higher than that of the control group. There was significant difference between the two groups （P 〈 0.05 ）. Conclusion The application of anti - Helico- bacter pylori on the basis of the control group has a positive effect on the gastrointestinal reaction of patients with hematologic tumor chemotherapy, and can ef

关 键 词：抗幽门螺杆菌 血液肿瘤 化疗胃肠道反应 

分 类 号：R730.6[医药卫生—肿瘤] R733[医药卫生—临床医学]