血清HE4、NGAL和CA125联合检测对子宫内膜癌的临床诊断意义  

Clinical diagnostic significance of combined detection of serum HE4,NGAL and CA125 for endometrial carcinoma

作　　者：陈洈伟 徐丹[1] 王艳 杨书雄[1] 刘新群 林晓君[1] Chen Weiwei;Xu Dan;Wang Yan(Department of Pathology,People＇s Hospital of Songzi City in Hubei Province,Jingzhou 43420)

机构地区：[1]湖北省松滋市人民医院病理科,荆州434200

出　　处：《陕西医学杂志》2018年第11期1500-1502,共3页Shaanxi Medical Journal

摘　　要：目的:探讨血清人附睾分泌蛋白E4(HE4)、中性粒细胞明胶酶相关脂质载运蛋白(NGAL)和人卵巢癌抗原(CA125)联合检测在子宫内膜癌(EC)中的临床诊断价值。方法:选取EC患者40例作为A组,同期选取子宫良性疾病患者40例作为B组,并同期选取健康体检者40例作为C组,抽取三组患者的血清标本,并检测其血清HE4、NGAL及CA125水平,并对比血清HE4、NGAL和CA125单独检测与联合检测的阳性检出率,且于治疗1个月后检测A组患者血清HE4、NGAL和CA125水平变化。结果:治疗前,A组患者血清HE4、NGAL和CA125水平明显高于B组和C组(P<0.05);而B组患者血清HE4、NGAL和CA125水平与C组比较无统计学差异(P>0.05);治疗前,A组血清HE4、NGAL和CA125联合检测阳性率(87.50%)明显高于血清HE4、NGAL和CA125单独检测(62.50%、60.00%、67.50%)(P<0.05);而B组和C组血清HE4、NGAL和CA125联合检测阳性率与血清HE4、NGAL和CA125单独检测比较无统计学差异(P>0.05);治疗后,A组患者血清HE4、NGAL和CA125水平明显低于治疗前(P<0.05)。结论:血清HE4、NGAL和CA125在EC组织中均明显表达,均可作为EC检测及手术疗效判断标志物,且血清HE4、NGAL和CA125联合检测可明显明显提高EC诊断准确性。Objective To investigate the clinical value of serum human epididymal secretory protein E4 （HE4）, neutrophil gelatinase associated lipid carrier protein （NGAL） and human ovarian cancer antigen （CA125） in the detection of endometrial carcinoma （EC）.Methods：40 case EC patients as A group, 40 cases of uterine benign disease patients as B group, and 40 healthy subjects were selected as group C, serum samples from three patients, and the detection of serum HE4, NGAL and CA125 levels, and serum HE4, contrast NGAL and CA125 detection and combined detection of the positive rate, and in 1 months after treatment to detect changes in A levels of serum HE4, NGAL and CA125 levels.Results：Before treatment, A group of serum HE4, NGAL and CA125 levels were significantly higher than that of B group and C group （ P 〈0.05）; And no significant difference between B group and CA125 NGAL, serum HE4 level and C group （ P 〉0.05）; A group before treatment, combined detection of serum HE4, NGAL and CA125. The rate （87.50%） was significantly higher than that of serum HE4, NGAL and CA125 respectively （62.50%, 60%, 67.50%） （ P 〈0.05）; And B group and C group serum HE4, combined detection of NGAL and CA125 with the positive rate of serum HE4, NGAL and CA125 detection alone had no significant （ P 〉0.05）; After the treatment. A group of serum HE4, NGAL and CA125 were significantly lower than those before treatment （ P 〈0.05）.Conclusion： Serum HE4, NGAL and CA125 are all expressed obviously in EC tissues. They can be used as markers for EC detection and operation efficacy evaluation. Combined detection of serum HE4, NGAL and CA125 can significantly improve the diagnostic accuracy of EC, so it is worthy of clinical promotion.

关 键 词：子宫内膜肿瘤/诊断 附睾分泌蛋白质类/血液 CA-125抗原/血液 @中性粒细胞明胶酶相关脂质载运蛋白 

分 类 号：R737.33[医药卫生—肿瘤]