DNA测序技术及其拼接算法综述  

Overview of DNA sequencing techniques and corresponding assembly algorithms

作　　者：李艳慧 张少强[1] LI Yanhui;ZHANG Shaoqiang(College of Computer and Information Engineering,Tianjin Normal University,Tianjin 300387,China)

机构地区：[1]天津师范大学计算机与信息工程学院,天津300387

出　　处：《天津师范大学学报（自然科学版）》2018年第5期1-9,共9页Journal of Tianjin Normal University：Natural Science Edition

基　　金：国家自然科学基金资助项目(61572358);天津市自然科学基金资助项目(16JCYBJC23600)

摘　　要：DNA测序技术已经历了四代的发展变化,本文对这四代DNA测序技术及相关的读序拼接算法进行综述.介绍了每一代测序技术的特点,详细分析了相关读序拼接算法的主要思想和特点,并对四代测序技术进行了比较.最后分析了目前拼接算法面临的挑战,并指出了读序拼接算法的新研究方向.DNA sequencing techniques have been around for four generations. A general overview of the four-generation DNA sequencing techniques and their related reads assembly algorithms are presented. The characteristics of each genera-tion of sequencing techniques are introduced,and the main ideas and characteristics of related read assembly algorithms are analyzed in detail through comparing the four-generation sequencing techniques. Finally,the challenges of the cur-rent assembly algorithms are analyzed,and the new research directions are pointed out.

关 键 词：DNA测序技术 读序 拼接算法 

分 类 号：Q503[生物学—生物化学]