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作 者:任殿泉 乌仁高娃 REN Dian-quan;Wurengaowa(Baotou Cancer Hospital,Baotou,Inner Mongolia,014030;Baotou Maternal and Child Health Care Institute,Baotou,Inner Mongolia,014030)
机构地区:[1]内蒙古包头市肿瘤医院,内蒙古包头014030 [2]包头市妇幼保健所,内蒙古包头014030
出 处:《智慧健康》2018年第22期72-73,共2页Smart Healthcare
摘 要:目的研究术前应用曲妥珠单抗联合新辅助化疗对乳腺癌患者血清中血管新生因子及乳腺组织中凋亡相关分子的影响。方法以我院就诊的乳腺癌患者进行研究观察,共选取50例,其中观察组25例,给予曲妥珠单抗联合新辅助化疗方式,对照组25例,给予新辅助化疗单一治疗方式,通过对比两组患者临床治疗效果。结果两组患者血清中血管新生因子与乳腺组织中凋亡相关分子表达水平治疗前均无明显差异,治疗后均显著优于治疗前,组间对比观察组显著优于对照组,P<0.05,差异有统计学意义。结论术前应用曲妥珠单抗联合新辅助化疗能够有效降低血清中血管新生因子与乳腺组织中凋亡相关分子表达水平,抑制肿瘤生长,安全性高,临床应用价值较高,值得推广。Objective To study the effect of preoperative trastuzumab combined with neoadjuvant chemotherapy on serum angiogenesis factors and apoptosis-related molecules in breast tissue of breast cancer patients. Methods A total of 50 cases of breast cancer patients were selected in our hospital. 25 patients in the observation group were treated with trastuzumab combined with neoadjuvant chemotherapy, and 25 cases in the control group were given a single treatment of neoadjuvant chemotherapy, and the clinical therapeutic effects of the two groups were compared. Results There was no significant difference between the serum levels of angiogenic factors in the two groups and the expression level of apoptosis related molecules in the breast tissue before treatment. After treatment, all of them were significantly better than those before treatment. The contrast group was significantly better than the control group, P〈 0.05. The difference was statistically significant. Conclusion Preoperative use of trastuzumab combined with neoadjuvant chemotherapy can effectively reduce the level of angiogenesis factor in serum and the expression level of apoptosis related molecules in breast tissue, inhibit the growth of tumor, and have high safety and high clinical value. It is worth popularizing.
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