糖皮质激素受体与肿瘤发生发展的关系  

The relationship between glucocorticoid receptor and tumor genesis and development

作　　者：周鹏[1] 江庆 胡孝刚 李忆东[1] ZHOU Peng;JIANG Qing;HU XiaoGang;LI YiDong(Teaching and Research Section of Pathophysiology,Faculty of Basic Medicine,Second Military Medical University,Shanghai 200433,China;Department of Otorhinolaryngology,No.101 Hospital of PLA,Wuxi Jiangsu 214044,China;Department of Geriatrics,No.101 Hospital of PLA,Wuxi Jiangsu 214044,China)

机构地区：[1]第二军医大学基础医学部病理生理学教研室,上海200433 [2]解放军第一〇一医院耳鼻喉科,江苏无锡214044 [3]解放军第一〇一医院老年科,江苏无锡214044

出　　处：《药学服务与研究》2018年第5期321-325,共5页Pharmaceutical Care and Research

基　　金：国家自然科学基金面上项目(81172100)

摘　　要：糖皮质激素受体(glucocorticoid receptor,GR)被激活后,通过与核内靶基因上的一段特定DNA序列结合,从而调控基因转录,发挥各种生物效应。GR广泛参与了生物体内多种生物学行为,在肿瘤发生发展调控方面,发挥了非常复杂的作用,表现出明显的组织特异性,在不同来源组织及细胞中的作用差异巨大。本文分析了GR与肿瘤迁移、侵袭、增殖等方面的关系。此外,本文还针对GR与其他核受体及microRNA之间的相互作用,对肿瘤的影响进行了综述,进一步阐述GR介导的生物学效应对肿瘤治疗及预后的影响。Glucocorticoid receptor （GR） regulates gene transcription by binding to a specific sequence of DNA of the targeted genes in the nucleus and exerts various biological effects when activated .GR participates in a wide range of biological behaviors in organisms, plays a very complex role in the regulation of tumor genesis and development , and displays an obvious tissue specificity . However, its role varies greatly in different tissues and cells .In this paper ,the relationship between GR and tumor was summarized from the aspects of migration ,invasion and proliferation .In addition ,this paper also aimed at the interae tion of GR and other nuclear receptors and microRNA ,and summarized the influence of GR induced biological behaviors on treatment and prognosis of tumors.

关 键 词：糖皮质激素受体 肿瘤 核受体 MICRORNA 综述 

分 类 号：R730.2[医药卫生—肿瘤] R979.1[医药卫生—临床医学]