胎盘多肽联合顺铂治疗胃癌腹腔积液疗效研究  

The efficacy of placenta polypeptide combined with cisplatin on gastric peritoneal effusio

作　　者：史碧霄 曹云 李烜[1] Shi Bixiao;Cao Yun;Li Xuan(Affiliated Hospital of Nanjing University of Chinese Medicine（Nanjing 210029)

机构地区：[1]南京中医药大学附属医院,南京210029

出　　处：《陕西中医》2018年第11期1504-1507,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：江苏省中医消化病临床医学研究中心课题(BL2014100)

摘　　要：目的:研究胎盘多肽联合顺铂对胃癌腹腔积液的改善情况、免疫功能指标的变化、生存质量及不良反应的影响。方法:将40例胃癌腹腔积液患者随机分为治疗组与对照组,每组各20例。对照组给予腹腔灌注化疗方案:将0.9%氯化钠2000ml和顺铂60mg混合均匀后行腹腔灌注,灌注化疗每14d行1次,共治疗4次;治疗组在对照组基础上加用胎盘多肽注射液8ml加入0.9%氯化钠注射液200ml中,2次/d,每次化疗期间连续治疗10d。两组均治疗4次后进行疗效评价。结果:治疗组和对照组患者腹腔积液的近期疗效无明显差别,差异无统计学意义(P>0.05);治疗后,治疗组患者CD_3^+、CD_4^+及CD_4^+/CD_8^+高于对照组,CD_8^+下降明显,差异比较有统计学意义(P<0.05);治疗后,治疗组患者KPS评分改善加稳定率比对照组高,不良反应发生率比对照组低,差异比较均有统计学意义(P<0.05)。结论:胎盘多肽联合顺铂对胃癌腹腔积液的改善无明显差别,但增强了患者的免疫功能,使患者生存质量得到提高,同时降低化疗产生的毒副反应,临床疗效较为理想。Objective：To investigate the improvement of ascites in gastric cancer, changes in immune function, quality of life, and adverse reactions of placenta polypeptide combined with cisplatin. Methods：40 patients with gastric cancer with ascites were randomly divided into treatment group and control group, with 20 cases in each group. The control group was given intraperitoneal chemotherapy： 0.9% sodium chloride 2000ml and cisplatin 60mg were mixed and peritoneal perfusion was performed. Perfusion chemotherapy was performed once every 14 days for a total of 4 treatments. The placebo peptide was added to the control group on the basis of the control group. 8ml of injection was added into 200ml of 0.9% sodium chloride injection, ivgtt, bid, 10 days after each chemotherapy. Both groups were treated 4 times and evaluated for efficacy. Results：There was no significant difference in the short-term efficacy of intraperitoneal effusion between the treatment group and the control group （ P 〉0.05）. After treatment, the CD 3 ＋ , CD^4＋ and CD^4＋ /CD^8＋ in the treatment group were significantly higher than those in the control group. CD^8＋ decreased significantly, the difference was statistically significant （ P 〈0.05）; after treatment, the KPS score was significantly higher in the treatment group than in the control group （ P 〈0.05）; the incidence of adverse reactions in the treatment group was significantly lower than the control group,the difference was statistically significant （ P 〈0.05）.Conclusions：Placenta polypeptide combined with cisplatin has no significant difference in the improvement of abdominal cavity effusion in gastric cancer, but it can improve the immune function of patients, improve the quality of life of patients, reduce adverse reactions, it is worth further promotion and application of the clinical.

关 键 词：胃肿瘤/中西医结合疗法 顺铂/治疗应用 胎盘提取物 

分 类 号：R735.2[医药卫生—肿瘤]