m6A reader suppression bolsters HSC expansion  

作　　者：Xinxin Huang Hal E. Broxmeyer 

机构地区：[1]Department of Microbiology and Immunology, indiana University School of Medicine, Indianapolis, IN, USA

出　　处：《Cell Research》2018年第9期875-876,共2页细胞研究（英文版）

摘　　要：The functional importance of N6-methyladenosine （m6A） modification in human health and disease has recently entered the research spotlight. In a recent paper published in Cell Research, Li et al. report a remarkable finding that deficiency in m6A reader Ythdf2 results in a striking expansion of mouse and human hematopoietic stem cells. RNA is made up of four nucleotides： A, C, G and U. Information on RNA molecules relies on their core sequence, and also their chemical modifications. RNA chemical modifications play important roles in various steps of RNA processing, degradation, translation, and thus in the regulation of gene expression. Amongst the more than 100 different chemical modifications on RNA identified.

关 键 词：HSC 读者 化学修正 RNA 核苷酸组成 聚光灯 阅读器 干细胞 

分 类 号：Q517[生物学—生物化学] TU528.042[建筑科学—建筑技术科学]