骨形态发生蛋白信号通路在牙根发育中的作用  

The role of bone morphogenetic protein signaling pathway in tooth root development

作　　者：刘苍维 周怡君 闫广兴 史册[1] 张雪[1] 胡月[1] 郝新青[1] 赵欢 孙宏晨[1] Liu Cangwei;Zhou Yijun;Yan Guangxing;Shi Ce;Zhang Xue;Hu Yue;Hao Xinqing;Zhao Huan;Sun Hongchen(Dept.of Oral Pathology,School and Hospital of Stomatology,Jilin University,Key Laboratory of Tooth Development and Bone Remodeling of Jilin Province,Changehun 130021,China)

机构地区：[1]吉林大学口腔医院病理科吉林省牙发育及颌骨重塑与再生重点实验室,长春130021

出　　处：《华西口腔医学杂志》2018年第5期559-563,共5页West China Journal of Stomatology

基　　金：国家重点研发专项基金(2016YFC1102800;2016YFC-1102804);国家自然科学基金(81320108011;81600843;816008-23;81600890);吉林省卫生厅基金(2016Q025);吉林省科技厅基金(20150414002GH;20160312020ZG;20170520016JH);吉林省卫生和计划生育委员会基金(2016C044-3)~~

摘　　要：骨形态发生蛋白(BMP)家族是调节细胞生命活动的重要因子,几乎参与了所有组织的发育。BMP介导的信号通路在牙发育过程中发挥十分重要的作用,而牙根发育是牙发育的一部分,是上皮和间充质相互作用的复杂过程。上皮和牙胚间充质中的BMP信号通路在牙根发育中的作用也有所不同,本文综述了BMP信号通路在牙根发育中作用的研究进展。The bone morphogenetic protein（BMP） family is an important factor in the regulation of cell ular life activities and in the development of almost all tissues. BMP-mediated signaling plays an important role in tooth root development, which is a part of tooth development. Epithelial and mesenchymal interactions are involved in tooth root development, but the BMP signaling pathway has a different effect on tooth root development in epithelial and mesenchymal. This review summarizes the advances of BMP signaling in tooth root development.

关 键 词：骨形态发生蛋白 牙发生 上皮根鞘 

分 类 号：R78[医药卫生—口腔医学]