帕洛诺司琼联合地塞米松预防鼻咽癌放疗中顺铂增敏所致恶心呕吐的临床分析  

Palonsetron combined with dexamethasone prevents nasopharyngeal carcinonm radiotherapy cisplatin- induced nausea and vomiting

作　　者：龙斌[1] 苏加利[1] 刘利民[1] 杨新辉[1] 施晓焱 龙君 李树梁 周光华[1] Long Bin;Su fiali;Liu Limin;Yang Xinhui;Shi Xiaoyan;Long Jun;Li Shuliang;Zhou Guanhua ;the(the Second Affiliated Hospital of Hunan Normal University）,Changsha,Hunan 410003 China;Special Clinic,the 163rd Hospital of PLA（the Second Affiliated Hospital of Hunan Normal ~/niverslty）,Changsha,Hunan 410003 China)

机构地区：[1]解放军第一六三医院湖南师范大学第二附属医院肿瘤科,湖南省长沙410003 [2]解放军第一六三医院湖南师范大学第二附属医院特诊科,湖南省长沙410003

出　　处：《中国基层医药》2018年第17期2197-2202,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的研究帕洛诺司琼联合地塞米松预防顺铂所致恶心呕吐的疗效及不良反应。方法选取解放军第一六三医院（湖南师范大学第二附属医院）2015年9月至2017年8月收治的鼻咽癌患者217例为研究对象，采用随机数字表法分成两组，顺铂化疗时只用帕洛诺司琼治疗组（对照组，n=108）和帕洛诺司联合地塞米松治疗组（研究组，n=109），观察两组临床疗效、不良反应。结果治疗1～6周，研究组头痛、头晕、疲劳发生率分别为7．2％、2．9％、3．4％，显著低于对照组的12．7％、6．0％、6．3％，两组差异均有统计学意义（x2=10．902、7．412、6．207，均P〈0．05）；预防恶心呕吐的控制率对照组为75．5％、研究组为80．9％，延迟期对照组为85．5％、研究组为91．0％，两组差异均有统计学意义（x2=5．615、9．442，均P〈0．05）。结论鼻咽癌放疗中顺铂增敏所致恶心呕吐采用帕洛诺司琼联合地塞米松治疗效果较好，且能减少帕洛诺司琼的药物不良反应。Objective To investigate the efficacy and adverse reactions of palonosetron and dexamethasone in preventing cisplatin - induced nausea and vomiting. Methods From September 2015 to August 2017, a total of 217 nasopharyngeal carcinpma patients in the 163rd Hospital of PLA were randomly divided into two groups according to the digital table The contnrol group （n = 108 ） was given pa!onosetron when used cisplatin treatment, the study group （n = 109） was given palonosetron combined with dexamethasone. The elinical efficacy and adverse reactions in the two groups were observexl. Results After treatment of 1 -6 weeks,the incidence,e rates of headache,dizziness and fatigue in the study group were 7.2% ,2.9% and 3.4% respectively,which were significantly lower than those in the control group （12.7%, 6.0% and 6.3% ）, the differences between the two groups were statistically significant （X2 = 10, 902, 7.412,6. 207 ,al! P 〈0.05）. The prevention rate of ngusea .and vomiting in the control group was 75.5% ,which in the study group was 80, 9% ,and at delay period,the prevention rote of nausea and vomiting in the control group was 85 5% ,which in the study group was 91.0% ,the differences between the two groups were statistically significant（X2 = 5 615,9. 442, all P 〈 0.05）. Conclusion Palonosetron and dexaroethasone are effective in the treatment of nasopha- ryngeal carcinoma with cisplatio - induced nauseg and vomiting, and can reduce the side effects of palonosetron.

关 键 词：帕洛诺司琼 地塞米松 恶心 呕吐 鼻咽肿瘤 

分 类 号：R739.63[医药卫生—肿瘤]