Current advances in solid free-form techniques for osteochondral tissue engineering  

作　　者：Joao Bebiano Costa Joana Silva-Correia Rui Luis Reis Joaquim Miguel Oliveira 

机构地区：[1]B's Research Group, I3Bs - Research Institute onBiomaterials, Biodegradables and Biomimetics, University ofMinho, Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine, AvePark,Parque de Ciencia e Tecnologia, Zona Industrial da Gandra,4805-017 Barco, Guimaraes, Portugal [2]ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarfies, Portugal [3]The Discoveries Centre for Regenerative and PrecisionMedicine, Headquarters at University of Minho,Avepark, 4805-017 Barco, Guimaraes, Portugal

出　　处：《Bio-Design and Manufacturing》2018年第3期171-181,共11页生物设计与制造（英文）

摘　　要：Osteochondral （OC） lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds＇ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form （SFF） techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关 键 词：Solid free-form OSTEOCHONDRAL Tissue engineering Scaffolds 

分 类 号：Q81[生物学—生物工程] Q-3