OSTEOCHONDRAL

作品数：66被引量：255H指数：9
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相关领域：医药卫生更多>>
相关作者：陶金刚徐海斌黄媛霞更多>>
相关机构：第三军医大学西南医院新乡医学院第一附属医院青岛市市立医院更多>>
相关期刊：《Chinese Journal of Traumatology》《Science China(Life Sciences)》《Regenerative Biomaterials》《Nano-Micro Letters》更多>>
相关基金：国家自然科学基金中国博士后科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Applications of type I and II collagen in osteochondral tissue engineering: Respective features and future perspectives被引量：1
《Medicine in Novel Technology and Devices》2024年第4期38-45,共8页Ruoyu Huang Xiaolian Niu Xueying Li Xiaoming Li 
The authors acknowledge financial support from the National Natural Science Foundation of China(No.32171345);the Beijing Nova Programme Interdisciplinary Cooperation Project(No.20230484464);the Hebei Provincial Natural Science Foundation of China(No.C2022104003);the Fok Ying Tung Education Foundation(No.141039);the International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China,and the 111 Project(No.B13003).
At present,osteoarthritis stands as one of the most prevalent degenerative musculoskeletal diseases globally.The inherent lack of self-healing capacity in articular cartilage presents a considerable obstacle in treati...
关键词：OSTEOARTHRITIS Osteochondral tissue engineering Type I collagen SCAFFOLD 
Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair
《Bioactive Materials》2024年第10期306-317,共12页Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang 
supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(NRF-2021K1A3A1A57086407,NRF-2021R1A2C2008821,NRF-2022R1I1A1A01071991);Arun Kumar Rajendran was supported by the National Research Foundation of Korea(NRF)grant Brain Pool program funded by the Ministry of Science and ICT through the National Research Foundation of Korea(2020H1D3A1A04081286);The Institute of Engineering Research at Seoul National University provided research facilities,and additional support came from the SNU Engineering-Medicine Collaboration grant.
Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage interface.Multilayered or gradient scaffolds,often in co...
关键词：BIOCERAMIC Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair 
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration
《Bioactive Materials》2024年第8期305-320,共16页Cuijun Deng Chen Qin Zhenguang Li Laiya Lu Yifan Tong Jiaqi Yuan Feng Yin Yu Cheng Chengtie Wu 
The National Key Research and Development Program of China(2023YFB3813000);the National Natural Science Foundation of China(32271441,82102196,32225028);the Natural Science Foundation of Shanghai(21DZ1205600,22ZR1462800);Shanghai Municipal Education Commission Innovative Program(2023ZKZD27);State Key Laboratory of Molecular Engineering of Polymers(Fudan University,K2021-12).
Osteochondral regeneration involves the highly challenging and complex reconstruction of cartilage and subchondral bone.Silicon(Si)ions play a crucial role in bone development.Current research on Si ions mainly focuse...
关键词：DIATOMITE Si release Hierarchical scaffolds 3D printing Osteochondral regeneration 
Enhanced osteochondral regeneration with a 3D-Printed biomimetic scaffold featuring a calcified interfacial layer
《Bioactive Materials》2024年第6期317-329,共13页Di Wu Kaiwen Zheng Wenjing Yin Bin Hu Mingzhao Yu Qingxiao Yu Xiaojuan Wei Jue Deng Changqing Zhang 
supported by the National Natural Science Foundation of China(Grant No.82202690);the Shanghai Pujiang Program(2022PJD051);the China Postdoctoral Science Foundation(2022M712121);the Basic Science Program of Shanghai Sixth People’s Hospital(Grant No.ynqn202203).
The integrative regeneration of both articular cartilage and subchondral bone remains an unmet clinical need due to the difficulties of mimicking spatial complexity in native osteochondral tissues for artificial impla...
关键词：3D-printed scaffold Calcified interfacial layer CAV-1 Osteochondral regeneration Tasquinimod 
Integrating coaxial electrospinning and 3D printing technologies for the development of biphasic porous scaffolds enabling spatiotemporal control in tumor ablation and osteochondral regeneration
《Bioactive Materials》2024年第4期338-353,共16页Wenbao He Chunlin Li Shitong Zhao Zhendong Li Jing Wu Junjun Li Haichao Zhou Yunfeng Yang Yong Xu Huitang Xia 
supported by the National Natural Science Foundation of China(82302395 and 82001979);Natural Science Foundation of Shanghai(22YF1437400);Young Elite Scientists Sponsorship Program by CAST(2023QNRC001);Shandong Provincial Natural Science Foundation(Major Basic Research Program,ZR2019ZD38);Taishan Scholar Program of Shandong Province(To Huitang Xia,202211333);Natural Science Foundation of Shandong Province(ZR2020MH381);Academic Promotion Program of Shandong First Medical University(2019LJ005);Shandong First Medical University Culture Foundation(202201-09);Social Science Planning and Research Project of Shandong Province(21CTQJ08).
The osteochondral defects(OCDs)resulting from the treatment of giant cell tumors of bone(GCTB)often present two challenges for clinicians:tumor residue leading to local recurrence and non-healing of OCDs.Therefore,thi...
关键词：Spatiotemporal control Giant cell tumors of bone Shell-core structure Double-layered scaffold Osteochondral regeneration 
3D printedβ-sheet-reinforced natural polymer hydrogel bilayer tissue engineering scaffold被引量：3
《Science China(Technological Sciences)》2024年第4期1170-1184,共15页ZHAO XinRui NIE XiongFeng ZHANG XiaoPing SUN YaGe YANG Rong BIAN XinYu ZHANG Qian WANG HongYing XU ZiYang LIU WenGuang 
supported by the National Key Research and Development Program of China(Grant No.2018YFA0703100)。
It remains a significant challenge to fabricate natural polymer(NP)hydrogels with anti-swelling ability and high strengths in the physiological environment.Herein,theβ-sheet-reinforced NP hydrogel is developed by cop...
关键词：silk fibroin Β-SHEET high-strength hydrogel natural polymer osteochondral regeneration 
Full-thickness osteochondral defect repair using a biodegradable bilayered scaffold of porous zinc and chondroitin sulfate hydrogel被引量：4
《Bioactive Materials》2024年第2期400-414,共15页Fan Yang Yageng Li Lei Wang Haodong Che Xin Zhang Holger Jahr Luning Wang Dong Jiang Hongjie Huang Jianquan Wang 
supported by grants from the National Natural Science Foundation of China(grant numbers:82072403,82072428,82272571,82267020,82372418,52201294);Beijing Natural Science Foundation Haidian Original Innovation Joint Fund Frontier Project(L212052);Beijing Natural Science Foundation(L212014);Prosperos project,funded by the Interreg VA Flanders-The Netherlands program,CCI Grant No.2014TC16RFCB04;the Interdisciplinary Centre for Clinical Research(IZKF)of the Faculty of Medicine of the RWTH Aachen University(OC1-1).
The regeneration of osteochondral tissue necessitates the re-establishment of a gradient owing to the unique characteristics and healing potential of the chondral and osseous phases.As the self-healing capacity of hya...
关键词：Chondroitin sulfate hydrogel Additive manufacturing Porous Zn scaffold Osteochondral regeneration 
3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface被引量：2
《The Innovation》2024年第1期88-97,共10页Yijian Zhang Duo Li Yang Liu Liuqi Peng Dongdong Lu Pinpin Wang Dongxu Ke Huilin Yang Xuesong Zhu Changshun Ruan 
This work was supported by grants from the National Key R&D Program of China(Grant Nos.2018YFA0703100 and 2022YFC2502902);the National Nature Science Foundation of China(Grant Nos.82072442,82272494,82072082,32122046,32101102);the Orthopaedic Medical Innovation Center of Jiangsu(CXZX202209);Key Laboratory of Orthopaedics of Suzhou(SZS2022017);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Shenzhen Fundamental Research Foundation(Grant Nos.JSGG20210629144537007,JCYJ20210324115814040,and JCYJ20210324113001005).
Reconstruction of osteochondral(OC)defects represents an immense challenge due to the need for synchronous regeneration of special stratified tissues.The revolutionary innovation of bioprinting provides a robust metho...
关键词：PRINTING STRATIFIED BOOST 
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells被引量：1
《World Journal of Stem Cells》2024年第2期176-190,共15页Yu-Su Wang Wen-Hui Chu Jing-Jie Zhai Wen-Ying Wang Zhong-Mei He Quan-Min Zhao Chun-Yi Li 
National Natural Science Foundation of China,No.U20A20403;This study was conducted in accordance with the Animal Ethics Committee of the Institute of Antler Science and Product Technology,Changchun Sci-Tech University(AEC No:CKARI202309).
BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown...
关键词：Osteochondral defect repair Mesenchymal stem cells Extracellular matrix DECELLULARIZATION Antler stem cells Reserve mesenchymal cells Xenogeneic 
In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug被引量：2
《Nano-Micro Letters》2024年第1期341-359,共19页Jiawei Kang Yaping Li Yating Qin Zhongming Huang Yifan Wu Long Sun Cong Wang Wei Wang Gang Feng Yiying Qi 
the Natural Science Foundation of China(Grant Nos.82072413,82101649);National Key Research and Development Program of China(Grant Nos.2021YFE0105400).
The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,sp...
关键词：Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a 
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