Applications of type I and II collagen in osteochondral tissue engineering: Respective features and future perspectives  

作　　者：Ruoyu Huang Xiaolian Niu Xueying Li Xiaoming Li 

机构地区：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China

出　　处：《Medicine in Novel Technology and Devices》2024年第4期38-45,共8页医学中新技术与新装备(英文)

基　　金：The authors acknowledge financial support from the National Natural Science Foundation of China(No.32171345);the Beijing Nova Programme Interdisciplinary Cooperation Project(No.20230484464);the Hebei Provincial Natural Science Foundation of China(No.C2022104003);the Fok Ying Tung Education Foundation(No.141039);the International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China,and the 111 Project(No.B13003).

摘　　要：At present,osteoarthritis stands as one of the most prevalent degenerative musculoskeletal diseases globally.The inherent lack of self-healing capacity in articular cartilage presents a considerable obstacle in treating osteoarthritis.Tissue engineering emerged as a promising strategy for the regeneration of osteochondral defects.Collagen,a primary component of bone and cartilage,stands out as a widely utilized natural material in osteochondral tissue engineering.Among various collagen types,Type I and type II collagen are notably prominent in this field.This review initially summarizes the advantageous and disadvantageous properties of type I/II collagen in osteochondral tissue engineering,proceeds to introduce their applications in this context,and concludes with a prospective outlook on the future development of type I/II collagen's applications.

关 键 词：OSTEOARTHRITIS Osteochondral tissue engineering Type I collagen SCAFFOLD 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]